Correlation Between Angle Closure Glaucoma Data and Lens Zonule Status

NCT06184620 | Completed

• 1 other identifier: YXLL-KY-2023(047)
• Study Type: observational
• Target: 263
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to discuss the correlation between primary angle-closure glaucoma and the state of the suspended ligament of the lens and the pathogenesis of PACG by measuring the biological data of primary angle-closure glaucoma and observing its anatomical changes.

Conditions

Primary Angle Closure Glaucoma

Keywords

primary angle closure glaucoma; UBM; lens zonule

Outcome Measures

Primary Outcomes (2)

• Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD),

  Axial Length (AL), Lens Thickness (LT),Lens Vault (LV), Pupil Diameter (PD),

  before operation

• Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500μm (AOD500) in the upper, lower, nasal and temporal directions

  Anterior Chamber Depth (ACD) in seat and rectum position, White To White (WTW), pupil vault (LV), pupil diameter (PD), The Lens Zonular Length (LZL) and Angle Opening Distance at 500μm (AOD500) in the upper, lower, nasal and temporal directions

  before operation

Study Arms (2)

PACG group

All patients in the experimental group met the diagnostic criteria of primary angle-closure glaucoma in the Chinese Glaucoma Guidelines(2020).

control group

The depth of the anterior chamber is normal, and the whole corner of the chamber is open; The cup-to-plate ratio is less than 0.5; No family history of glaucoma

Eligibility Criteria

• Age: 47 Years - 91 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

From December 2020 to January 2022, patients with primary angle-closure glaucoma and normal control patients were diagnosed for the first time and intended to undergo cataract surgery in the ophthalmology department of the First Affiliated Hospital of Shandong First Medical University (Shandong Qiandfo Hospital).

You may qualify if:

• The depth of the anterior chamber is normal, and the whole corner of the chamber is open;
• The cup-to-plate ratio is less than 0.5;
• No family history of glaucoma.

You may not qualify if:

• Previous history of trauma or internal eye surgery in both eyes or one eye;
• Used "pilocarpine", "atropine" and other drugs to change the size of the pupil and the shape of the chamber Angle within 1 week;
• Combined with other eye diseases affecting the Angle and suspension ligament, such as uveitis, ciliary cyst, high myopia, retinal diseases, etc.;
• Can not cooperate with UBM and Angle scopy;
• Refuse to participate in this researcher.

Sponsors & Collaborators

• Guangfu Dang: lead

Study Sites (1)

guangfu Dang

Jinan, Shandong, 250000, China

Location

MeSH Terms

Conditions

Glaucoma, Angle-Closure

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: December 14, 2023
• First Posted: December 28, 2023
• Study Start: December 1, 2020
• Primary Completion: March 30, 2023
• Study Completion: March 30, 2023
• Last Updated: December 28, 2023

Record last verified: 2023-12

Locations

CN (1)