NCT02276807

Brief Summary

The purpose of the Improving Mood in Veterans in Primary Care (IIR 14-047) is to evaluate a brief educational individual workshop that is meant to help Veterans better understand feelings of sadness and ways to improve their mood. This study is intended to evaluate and establish the workshop's effectiveness for use with Veterans in primary care settings. The study involves up to 6 in-person meetings and 6 telephone interviews across a 6-month period of time. Approximately 144 Veterans will participate in the study. Using a procedure like the flip of a coin, the participants will have a one in two chance of receiving the brief educational workshop or treatment as usual condition.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
140

participants targeted

Target at P50-P75 for not_applicable depression

Timeline
Completed

Started Mar 2015

Typical duration for not_applicable depression

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 8, 2014

Completed
20 days until next milestone

First Posted

Study publicly available on registry

October 28, 2014

Completed
5 months until next milestone

Study Start

First participant enrolled

March 23, 2015

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2018

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2018

Completed
11 months until next milestone

Results Posted

Study results publicly available

June 14, 2019

Completed
Last Updated

July 1, 2019

Status Verified

June 1, 2019

Enrollment Period

2.9 years

First QC Date

October 8, 2014

Results QC Date

March 1, 2019

Last Update Submit

June 19, 2019

Conditions

Keywords

DepressionBehavioral SymptomsMental DisordersDepressive Disordersuicidal ideationprimary health careVeterans

Outcome Measures

Primary Outcomes (1)

  • Change From Baseline in Depressive Symptoms at 12 Weeks

    The investigators will use the Patient Health Questionnaire-9 (PHQ-9) to assess depressive symptoms at baseline and 12 weeks. The minimum value is 0 and the maximum value is 27. Higher scores mean a worse outcome.

    Baseline and 12 weeks

Secondary Outcomes (3)

  • Change From Baseline in Quality of Life at 12 Weeks

    Baseline and 12 weeks

  • Change From Baseline in Sleep Disturbances at 12 Weeks

    Baseline and 12 weeks

  • Change From Baseline in the Level of Reward/Positive Mood When Engaging in Various Experiences at 12 Weeks

    Baseline and 12 weeks

Other Outcomes (1)

  • Change From Baseline in the Level of Intensity of Suicidal Ideation at 12 Weeks

    Baseline and 12 weeks

Study Arms (2)

Brief Behavioral Activation

EXPERIMENTAL

This is a 4-session individual workshop using behavioral activation techniques. Emphasis is placed upon understanding the individuals values and increasing the number of pleasurable activities aligned with the individuals values.

Behavioral: Brief Behavioral Activation

Usual Care

ACTIVE COMPARATOR

This is the usual care condition, where participants often times will be provided with brief treatment in primary care that can take many forms.

Other: Usual Care

Interventions

This is a 4-session individual workshop using behavioral activation techniques.

Brief Behavioral Activation

Primary care patients will be referred to the integrated behavioral health provider to receive brief treatment in primary care.

Also known as: Usual Care condition
Usual Care

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Veterans:
  • aged 18 years
  • seeking or receiving primary care services at the Syracuse, Canandaigua, or Buffalo VA Medical Centers
  • reporting at least moderate depressive symptoms
  • stable course of antidepression medications
  • stable course of outpatient treatment for anxiety or substance use disorders

You may not qualify if:

  • Veterans who are:
  • unable to demonstrate an understanding of the informed consent
  • non-English speaking
  • reporting imminent risk of suicide
  • have an unstable psychiatric condition
  • currently involved in treatment for depression
  • recently started antidepression medication or outpatient treatment for anxiety or substance use disorder
  • currently involved or completed inpatient or intensive outpatient treatment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

VA Western New York Healthcare System, Buffalo, NY

Buffalo, New York, 14215, United States

Location

Canandaigua VA Medical Center, Canandaigua, NY

Canandaigua, New York, 14424, United States

Location

Syracuse VA Medical Center, Syracuse, NY

Syracuse, New York, 13210, United States

Location

Related Publications (1)

  • Funderburk JS, Pigeon WR, Shepardson RL, Wade M, Acker J, Fivecoat H, Wray LO, Maisto SA. Treating depressive symptoms among veterans in primary care: A multi-site RCT of brief behavioral activation. J Affect Disord. 2021 Mar 15;283:11-19. doi: 10.1016/j.jad.2021.01.033. Epub 2021 Jan 14.

Related Links

MeSH Terms

Conditions

DepressionBehavioral SymptomsMental DisordersDepressive DisorderSuicidal Ideation

Condition Hierarchy (Ancestors)

BehaviorMood DisordersSuicideSelf-Injurious Behavior

Limitations and Caveats

Limited to a Veteran population willing to engage in a clinical trial, lack of ability to clarify the impact of BA-PC from the impact of BA-PC with regular assessment of depressive symptoms which likely decreased power of sample size unexpectedly

Results Point of Contact

Title
Dr. Jennifer Funderburk
Organization
VA Center for Integrated Healthcare

Study Officials

  • Jennifer Schum Funderburk, PhD

    Syracuse VA Medical Center, Syracuse, NY

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
FED
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 8, 2014

First Posted

October 28, 2014

Study Start

March 23, 2015

Primary Completion

March 1, 2018

Study Completion

July 31, 2018

Last Updated

July 1, 2019

Results First Posted

June 14, 2019

Record last verified: 2019-06

Locations