NCT02276573

Brief Summary

Oral lichen planus (OLP) is a chronic inflammatory and relapsing. The average prevalence is 1 to 4%. The clinics forms are many and symptoms are varied. The erosive form, painful and debilitating is characterized by erosive areas, ulcerated on an erythematous base with or without a keratinocyte lichenien network. The literature data moving towards an autoimmune origin, but the pathophysiological mechanisms of OLP remain unknown. This project represents the first part of a comprehensive project to examine the oral pathogenesis of different viruses (Herpes and papillomavirus HPV) and centered on Epstein-Barr Virus (EBV).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
13

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Mar 2015

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 24, 2014

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 28, 2014

Completed
5 months until next milestone

Study Start

First participant enrolled

March 30, 2015

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 10, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 10, 2016

Completed
Last Updated

March 24, 2026

Status Verified

March 1, 2026

Enrollment Period

12 months

First QC Date

October 24, 2014

Last Update Submit

March 20, 2026

Conditions

Lichen Planus, Oral

Outcome Measures

Primary Outcomes (1)

  • Measure of level of EBV nucleic acids

    day 1

Study Arms (1)

Oral lichen planus disease

EXPERIMENTAL

buccal cavity sample

Biological: buccal cavity sample

Interventions

buccal cavity sampleBIOLOGICAL
Oral lichen planus disease

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patient ≥ 18 years
  • Clinical and/or histological diagnosis of erosive or atrophic OLP
  • No signs of severe dysplasia at the sampling

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hôpital saint Roch

Nice, 06000, France

Location

Related Publications (1)

  • Raybaud H, Olivieri CV, Lupi-Pegurier L, Pagnotta S, Marsault R, Cardot-Leccia N, Doglio A. Epstein-Barr Virus-Infected Plasma Cells Infiltrate Erosive Oral Lichen Planus. J Dent Res. 2018 Dec;97(13):1494-1500. doi: 10.1177/0022034518788282. Epub 2018 Jul 13.

    PMID: 30004820RESULT

MeSH Terms

Conditions

Lichen Planus, Oral

Condition Hierarchy (Ancestors)

Mouth DiseasesStomatognathic DiseasesLichen PlanusLichenoid EruptionsSkin Diseases, PapulosquamousSkin DiseasesSkin and Connective Tissue Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 24, 2014

First Posted

October 28, 2014

Study Start

March 30, 2015

Primary Completion

March 10, 2016

Study Completion

March 10, 2016

Last Updated

March 24, 2026

Record last verified: 2026-03

Locations

FR(1)