Metabolic Syndrome and Non-alcoholic Fatty Liver During Pregnancy

NCT02276144 | Unknown

• 1 other identifier: Fatty liver in pregnancy
• Study Type: observational
• Target: 2,400
• Locations: 1 country
• Sites: 3

Brief Summary

The aim of this study is to evaluate the prevalence of metabolic syndrome, liver function abnormality and non-alcoholic fatty liver disease in early pregnancy patients, and the risk of pregnancy complications.

Conditions

Fatty Liver; Gestational Diabetes

Outcome Measures

Primary Outcomes (1)

• Compare prevalence of obstetric complications between non-alcoholic fatty liver and normal pregnant women

  Obstetrical complications include gestational diabetes, preeclampsia, etc Non-alcoholic fatty liver diagnosed by using liver ultrasound result of 1st trimester and blood test (AST, APT)

  From date of enrollment until the date of delivery, assessed up to 35wks

Interventions

Liver ultrasound OTHER

For evaluate whether fatty liver is exist or not

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

1st trimester pregnancy women with singleton

You may qualify if:

• Outpatient clinic patients of Seoul National University Hospital, Seoul Metropolitan Government Boramae Medical Center, Incheon Seoul Woman Hospital
• Agree with this study
• Do not drink excess amount of alcohol for recent 2 years

You may not qualify if:

• Do not agree with this study
• Do not perform blood tests
• Have underlying hepatobiliary diseases
• Take medications which can cause liver abnormalities

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (3)

Seoul Women's Hospital

Incheon, 402859, South Korea

RECRUITING

Seoul National University Hospital

Seoul, 110744, South Korea

RECRUITING

Seoul Metropolitan Goverment Seoul National University Boramae Medical Center

Seoul, 156707, South Korea

RECRUITING

Related Publications (2)

• Zhang J, Suo Y, Wang L, Liu D, Jia Y, Fu Y, Fan W, Jiang Y. Association between atherogenic index of plasma and gestational diabetes mellitus: a prospective cohort study based on the Korean population. Cardiovasc Diabetol. 2024 Jul 5;23(1):237. doi: 10.1186/s12933-024-02341-9.

  PMID: 38970008 DERIVED

• Lee SM, Hwangbo S, Norwitz ER, Koo JN, Oh IH, Choi ES, Jung YM, Kim SM, Kim BJ, Kim SY, Kim GM, Kim W, Joo SK, Shin S, Park CW, Park T, Park JS. Nonalcoholic fatty liver disease and early prediction of gestational diabetes mellitus using machine learning methods. Clin Mol Hepatol. 2022 Jan;28(1):105-116. doi: 10.3350/cmh.2021.0174. Epub 2021 Oct 15.

  PMID: 34649307 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

serum for lab tests

MeSH Terms

Conditions

Fatty Liver; Diabetes, Gestational

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Joong Shin Park, MD PhD

  Seoul National University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

JEONGEUN Kwon, MD

CONTACT

82-02-2072-3085; ccoolicoola@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 10, 2014
• First Posted: October 28, 2014
• Study Start: November 1, 2014
• Primary Completion: December 1, 2021
• Study Completion: December 1, 2021
• Last Updated: March 20, 2020

Record last verified: 2019-04

Locations

KR (3)