Evaluation of Conventional Antibiotic Prophylaxis During a Change of Hip or Knee Infected at a Time

NCT02272205 | Completed

• 1 other identifier: 004-14
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

Infection is a serious complications after undergoing total hip replacement. It occurs in about 1% of cases. The optimal treatment of these infections is discussed. The team validated by international publications change strategy of the infected prosthesis at a time. Antibiotic prophylaxis has significantly reduced the infection intraoperative contamination in orthopedic surgery rates. It must be conventionally administered before the surgical incision. In response to infection, it is typically recommended to start this antibiotic after the completion of the deep bacteriological samples, so as not to negate the risk of these samples by the prior administration of antibiotics. This attitude, however, is not formally validated by the scientific literature. In contrast, two recent publications challenge this practice, and suggest the use of a conventional antibiotic prophylaxis even in septic interventions. Our multidisciplinary team opted for a few months for this new strategy. We wish to evaluate the influence of this new approach results in the treatment of infection in total hip or knee.

Conditions

Total Hip Replacement

Keywords

Hip replacement; Knee replacement; Knee infection; Hip infection; Antibiotic prophylaxis

Outcome Measures

Primary Outcomes (1)

• concordance of pre-and intraoperative bacteriological documentation

  concordance of pre-and intraoperative bacteriological documentation (division into 3 classes: complete, partial, no - Chi-square test

  preoperative; intraoperative

Secondary Outcomes (1)

• rates to relapse of the initial infection or a new infection

  preoperative; intraoperative

Interventions

Retrospective analysis of records OTHER

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

80 patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.

You may qualify if:

• patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.

You may not qualify if:

• patients operated in service before January 2012 and after July 2013 for treatment of an infection of total hip or knee.

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 20, 2014
• First Posted: October 22, 2014
• Study Start: November 1, 2014
• Primary Completion: October 31, 2017
• Study Completion: October 31, 2017
• Last Updated: September 5, 2025

Record last verified: 2025-09