Acute Effects of High Intensity Interval Exercise on Executive Function

NCT02270528 | Completed

• 1 other identifier: HM20000451
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine the acute effects of high intensity interval ergometry on peripheral concentrations of lactate and hydrogen ions, as well as cognitive function. Approximately 60 healthy, college-aged males will participate in the Wisconsin Card Sorting Task (WCST), a measure of executive function, two times over a span of two weeks. Prior to the WCST, participants will complete either a warm-up, a warm-up and high intensity interval exercise, or a stationary period. Changes in lactate, pH, and WCST score will be evaluated between and within groups in relation to the presence of the high intensity exercise stimulus.

Conditions

High Intensity Interval Exercise (HIIE); Pain Perception; Wisconsin Card Sorting Task

Outcome Measures

Primary Outcomes (3)

• Peripheral Blood Lactate

  Lactate is known to increase during exercise. At each time frame, \~15mL of blood will be sampled from a subject via intravenous catheter. From this sample, blood will be analyzed for lactate using a YSI2300.

  8 times total; 2 at Baseline (Day 1; Minute 14 and Minute 29), 3 in session 1 (Day 3; Minute 2, Minute 18, and Minute 29), and 3 in session 2 (Day 17; Minute 2, Minute 18, and Minute 29); Maximum Time Frame at Session 2 (Day 17, Minute 29)

• Peripheral Hydrogen Ions, Peripheral Blood pH

  pH decreases during rigorous or intense exercise. At each time frame, \~15mL of blood will be sampled from a subject via intravenous catheter. From this sample, blood will be analyzed for Hydrogen Ions (pH) via a pH electrode.

  8 times total; 2 at Baseline (Day 1; Minute 14 and Minute 29), 3 in session 1 (Day 3; Minute 2, Minute 18, and Minute 29), and 3 in session 2 (Day 17; Minute 2, Minute 18, and Minute 29); Maximum Time Frame at Session 2 (Day 17, Minute 29)

• Executive Function

  Executive Function deals with the ability to problem solve, plan, and make decisions. The Wisconsin Card Sorting Task (WCST) is a computerized version of a task of executive function. Categories completed will be used as the measure of executive function ability.

  2 times total, 1 in session 1 (Day 3; Minute 20), 1 in session 2 (Day 17, Minute 20); Maximum Time Frame at Session 2 (Day 17, Minute 20)

Secondary Outcomes (3)

• Ratings of Perceived Pain (RPP)

  8 times total; 2 at Baseline (Day 1; Minute 15 and Minute 30), 3 in session 1 (Day 3; Minute 3, Minute 19, and Minute 30), and 3 in session 2 (Day 17; Minute 3, Minute 19, and Minute 30); Maximum Time Frame at Session 2 (Day 17, Minute 30)

• Ratings of Perceived Exertion (RPE)

  8 times total; 2 at Baseline (Day 1; Minute 15 and Minute 30), 3 in session 1 (Day 3; Minute 3, Minute 19, and Minute 30), and 3 in session 2 (Day 17; Minute 3, Minute 19, and Minute 30); Maximum Time Frame at Session 2 (Day 17, Minute 30)

• Emotion (Feeling Scale, FS)

  8 times total; 2 at Baseline (Day 1; Minute 15 and Minute 30), 3 in session 1 (Day 3; Minute 3, Minute 19, and Minute 30), and 3 in session 2 (Day 17; Minute 3, Minute 19, and Minute 30); Maximum Time Frame at Session 2 (Day 17, Minute 30)

Study Arms (3)

HIT1

EXPERIMENTAL

This group will participate in the Wisconsin Card Sorting Task (WCST) two times. During the first attempt, prior to the WCST, this group will perform a warm-up and the high intensity interval exercise. The second attempt, prior to the WCST, this group will perform a warm-up and 5-minute stationary period. All measures of independent variables (pH, lactate, RPE, RPP, and FS) will be the same for all groups.

Behavioral: Exercise; Behavioral: Cognitive Task

HIT2

EXPERIMENTAL

This group will participate in the Wisconsin Card Sorting Task (WCST) two times. During the first attempt, prior to the WCST, this group will perform a warm-up and a 5-minute stationary period. The second attempt, prior to the WCST, this group will perform a warm-up and the high intensity interval exercise. All measures of independent variables (pH, lactate, RPE, RPP, and FS) will be the same for all groups.

Behavioral: Exercise; Behavioral: Cognitive Task

CON

OTHER

This group will participate in the Wisconsin Card Sorting Task (WCST) two times. During the first attempt and second attempt, prior to the WCST, this group will participate in a 15-minute stationary period. All measures of independent variables (pH, lactate, RPE, RPP, and FS) will be the same for all groups.

Behavioral: Cognitive Task

Interventions

Exercise BEHAVIORAL

10 seconds of sprinting on a bicycle ergometer against a resistance equivalent to 5.5% of a participant's body weight, followed by 20 seconds of rest, repeated 10 times. (\~5 minutes)

HIT1; HIT2

Cognitive Task BEHAVIORAL

The Wisconsin Card Sorting Task (WCST) is a measure of Executive Function.

CON; HIT1; HIT2

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male college students
• Ages of 18-35 years old
• Body fat percent \< 25%

You may not qualify if:

• Moderate to high risk for cardiovascular disease
• Reporting any known physical or psychological diseases or disorders
• Participating in certain prescription and/or illegal drug use
• Smoking
• Body fat percent \> 25%
• Those having undergone any surgery, serious injury, or hospitalization within the past five years
• Those having experienced a major life event (eg divorce, family death) in the past five years

Sponsors & Collaborators

• Virginia Commonwealth University: lead

Study Sites (1)

Clinical Research Unit, MCVH-VCU

Richmond, Virginia, 23228, United States

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Edmund O Acevedo, PhD

  Virginia Commonwealth University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 25, 2014
• First Posted: October 21, 2014
• Study Start: October 1, 2014
• Primary Completion: July 1, 2018
• Study Completion: July 1, 2018
• Last Updated: August 21, 2018

Record last verified: 2018-08

Locations

US (1)