Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension

NCT02270216 | Unknown

• 1 other identifier: KhonKaenU
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Aim to study the exercise responses to both static and dynamic exercise in elderly people with and without essential isolated systolic hypertension, seeking to identify potentially dangerously high responses

Conditions

Cardiovascular Responses in Elderly With Isolated Systolic Hypertension

Keywords

isolated systolic hypertension; exercise pressor responses

Outcome Measures

Primary Outcomes (2)

• Blood pressure

  Blood pressure will be measured with a digital bedside monitor. An inflatable cuff placed around the subject's arm one inch above the patient's elbow over the brachial artery. Resting blood pressure will be measured in a sitting position after having rested for 15 minutes

  6 month

• heart rate

  Heart rate will be measured at rest and during exercise. ECG electrode will be attached in lead II configuration and connected to the BIOPAC system. The heart rate will be determined from the R-R interval with the data analyzed by the BIOPAC system.

  6 month

Study Arms (2)

elderly with isolated systolic hypertension

ACTIVE COMPARATOR

over 60 years of age with essential isolated systolic hypertension (stage I-II base on recommendation of JNC-VII) for the hypertension group. Good communication, independent physical activity. The healthy subject should be non-smokers, free of any signs or symptoms of disease as revealed by medical history

Procedure: static hand grip exercise; Procedure: cycling exercise

healthy elderly

ACTIVE COMPARATOR

over 60 years of age with normal blood pressure in the healthy group. Good communication, independent physical activity. The healthy subject should be non-smokers, free of any signs or symptoms of disease as revealed by medical history

Procedure: static hand grip exercise; Procedure: cycling exercise

Interventions

static hand grip exercise PROCEDURE

The static exercise pressor response will be tested using isometric handgrip of the left hand. The forearm will be supported on an arm rest with elbow flexed. The maximum voluntary contraction force will be measured as the best of three attempts. After 2 minute rest, subjects will perform 2 minute of isometric hand grip contraction at 30% MVC. Circulatory occlusion(50 mmHg supra-systolic pressure) will start at 1.30 min and continued for 2 minute after the end of the isometric handgrip exercise. Following release of the cuff there will be a further 2 minutes recovery. The blood pressure and heart rate will be measured at the end of each minute during rest, isometric handgrip, circulatory occlusion and recovery. Subjects will be instructed to breathe normally during the test and avoid any Valsalva maneuver; breathing frequency will be monitored during the handgrip pressor test using capnography.

Also known as: static exercise

elderly with isolated systolic hypertension; healthy elderly

cycling exercise PROCEDURE

The dynamic exercise will be with the subject sitting on a cycle ergometer (Monark 828 E). Resting heart rate will be measured for 2 minutes before the start of exercise. The exercise level will be limited to 50% of the estimated maximum heart rate reserve. Maximum heart rate will be estimated as 207-0.7\*age and heart rate reserve (HRR) as maximum minus resting heart rate. Subjects will pedal at 50 rpm for 1 min with no load and then 3 minutes against a load of 0.5 Kp (25W) increasing to a load of 1 Kp for the next 3 minutes and to 1.5 Kp, if necessary, for a further 3 minutes until the target heart rate of 50% HRR is reached. Subjects will be asked about their level of perception of dyspnea using a visual analog scale every 3 minutes at the end of each load. At the end of the exercise, the subjects will sit for ten minutes.

elderly with isolated systolic hypertension; healthy elderly

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects should be over 60 years of age with essential isolated systolic hypertension (stage I-II base on recommendation of JNC-VII) for the hypertension group and normal blood pressure in the healthy group. Good communication, independent physical activity. The healthy subject should be non-smokers, non-obese, free of any signs or symptoms of disease as revealed by medical history

You may not qualify if:

• Essential hypertension stage III or secondary hypertension, any history of respiratory disease, heart disease, renal disease, blindness, cerebrovascular disease, exercise limited by pain

Sponsors & Collaborators

• Sahachat Aueyingsak: lead

Study Sites (1)

Khon Kaen University

Khon Kaen, Changwat Khon Kaen, 40000, Thailand

Location

Related Links

• The seventh report of the joint national committee on prevention, Detection, evaluation, and treatment of high blood pressure
• Update on pathophysiology and treatment of hypertension in the elderly.
• Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex
• Effect of muscle metaboreflex activation on carotid-cardiac baroreflex function in humans
• The effectiveness of exercise training in lowering blood pressure: a meta-analysis of randomised controlled trials of 4 weeks or longer
• Effects of aerobic training on exaggerated blood pressure response to exercise in African-Americans with severe systemic hypertension treated with indapamide +/- verapamil +/- enalapril
• Aging and arterial stiffness
• RESPeRATE: nonpharmacological treatment of hypertension.

MeSH Terms

Conditions

Isolated Systolic Hypertension

Interventions

Exercise

Condition Hierarchy (Ancestors)

Essential Hypertension; Hypertension; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Chulee Jones, PhD

  Faculty of Associated Medical Science, Khon Kaen University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Master's Degree Student

Study Record Dates

• First Submitted: October 14, 2014
• First Posted: October 21, 2014
• Study Start: May 1, 2014
• Primary Completion: October 1, 2014
• Last Updated: October 21, 2014

Record last verified: 2014-10

Locations

TH (1)