NCT02262702

Brief Summary

The aim of this observational study is to compare the use of an extended release paracetamol formulation with standard paracetamol in a cohort of Australian concessional patients with osteoarthritis (OA), to assess differences in prescribing patterns and patient compliance.

Trial Health

15
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Jan 2013

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2013

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2013

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

May 23, 2013

Completed
1.4 years until next milestone

First Posted

Study publicly available on registry

October 13, 2014

Completed
Last Updated

January 25, 2016

Status Verified

January 1, 2016

Enrollment Period

Same day

First QC Date

May 23, 2013

Last Update Submit

January 21, 2016

Conditions

Outcome Measures

Primary Outcomes (2)

  • Relative number of prescriptions of an extended release paracetamol formulation and a standard release paracetamol formulation.

    Number of episodes of treatment for OA with the extended release formulation and the standard release formulatins will be counted.

    January 2009 to December 2010

  • Relative treatment compliance with an extended release paracetamol formulation and a standard release paracetamol formulation

    Interval between the repeat doses of extended release paracetamol formulation and the standard release paracetamol formulation.

    January 2009 to December 2010

Study Arms (2)

Extended Release Paracetamol

Participants prescribed with extended release paracetamol tablet containing 665 mg paracetamol.

Drug: Paracetamol 665 mg

Standard Paracetamol

Participants prescribed with standard paracetamol tablet containing 500 mg paracetamol.

Drug: Paracetamol 500 mg

Interventions

Paracetamol 665 mg tablet

Also known as: Panadol Osteo
Extended Release Paracetamol

Paracetamol 500 mg tablet

Standard Paracetamol

Eligibility Criteria

Age50 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Cohort of Australian concessional patients with osteoarthritis

You may qualify if:

  • Participants prescribed with a paracetamol product and categorized as a concessional patient
  • Participants with new episodes of OA (no history of OA paracetamol in previous 12 months) or suffering from chronic OA (history of OA paracetamol in the previous 12 months)

You may not qualify if:

  • Participants with Rheumatoid arthritis or other auto-immune inflammatory conditions
  • Participants receiving the following anti-rheumatoid therapies:Immunimodulators such as methotrexate, leflunamide and TNF blockers
  • Participants receiving treatment for cancer pain

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Osteoarthritis

Interventions

Acetaminophen

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Intervention Hierarchy (Ancestors)

AcetanilidesAnilidesAmidesOrganic ChemicalsAniline CompoundsAmines

Study Officials

  • GSK Clinical Trials

    GlaxoSmithKline

    STUDY DIRECTOR
0

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 23, 2013

First Posted

October 13, 2014

Study Start

January 1, 2013

Primary Completion

January 1, 2013

Study Completion

January 1, 2013

Last Updated

January 25, 2016

Record last verified: 2016-01