Taste Physiology in Healthy, Normal-weight Volunteers

NCT02255812 | Completed

• 1 other identifier: EKBB 289/12/2
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Taste physiology describes five main taste qualities in humans: sweet, sour, salty, umami and bitter. The receptors found on the tongue are also found in the entire gut. The correlation of stimulation of these gut receptors and brain activity has not yet been examined. The objectives are to investigate the effect of different taste substances on i) regional brain activity and ii) satiation peptide release.

Conditions

Exploratory Behavior

Outcome Measures

Primary Outcomes (1)

• regional brain activity assessed by functional Magnetic Resonance Imaging (fMRI)

  Changes in resting state functional connectivity

  changes from baseline to one hour after treatment

Secondary Outcomes (2)

• gastrointestinal satiation peptide secretion

  changes from baseline to one hour after treatment

• glucose and insulin secretion

  changes from baseline to one hour after treatment

Study Arms (6)

200 mL tap water

PLACEBO COMPARATOR

Single intragastric instillation of 200 mL tap water via nasogastric tube

Dietary Supplement: Single intragastric instillation of 200 mL tap water via nasogastric tube

2 g citric acid

ACTIVE COMPARATOR

Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube

Dietary Supplement: Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube

2 g salt

ACTIVE COMPARATOR

Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube

Dietary Supplement: Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube

0.017 g quinine

ACTIVE COMPARATOR

Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube

Dietary Supplement: Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube

1 g monosodium glutamate

ACTIVE COMPARATOR

Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube

Dietary Supplement: Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube

25 g glucose

ACTIVE COMPARATOR

Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube

Dietary Supplement: Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube

Interventions

Single intragastric instillation of 200 mL tap water via nasogastric tube DIETARY_SUPPLEMENT

200 mL tap water

Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube DIETARY_SUPPLEMENT

2 g citric acid

Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube DIETARY_SUPPLEMENT

2 g salt

Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube DIETARY_SUPPLEMENT

0.017 g quinine

Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube DIETARY_SUPPLEMENT

1 g monosodium glutamate

Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube DIETARY_SUPPLEMENT

25 g glucose

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• right-handed healthy males
• Body-mass index of \< 25
• Age 18-45 years
• no drugs
• non-smoking

You may not qualify if:

• Smoking
• Substance abuse
• Regular intake of medications (except for oral contraceptives)
• Medical or psychiatric illness, especially: diabetes, pace-maker, claustrophobia
• History of gastrointestinal disorders
• Food allergies, glutamate intolerance
• Body piercings that cannot be removed

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead

Study Sites (1)

University Hospital

Basel, CH-4031, Switzerland

Location

MeSH Terms

Conditions

Exploratory Behavior

Interventions

Citric Acid; Salts; Quinine; Sodium Glutamate; Glucose

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Citrates; Tricarboxylic Acids; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Inorganic Chemicals; Cinchona Alkaloids; Alkaloids; Heterocyclic Compounds; Quinuclidines; Heterocyclic Compounds, Bridged-Ring; Quinolines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Glutamic Acid; Glutamates; Amino Acids, Acidic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Dicarboxylic; Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Officials

• Christoph Beglinger, MD

  University Hospital, Basel, Switzerland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 6, 2014
• First Posted: October 3, 2014
• Study Start: March 1, 2013
• Primary Completion: October 1, 2013
• Study Completion: October 1, 2013
• Last Updated: October 3, 2014

Record last verified: 2014-09

Locations

CH (1)