Frontoparietal Priority Maps as Biomarkers for MTBI

NCT02251002 | Completed

• 1 other identifier: 1408M53005
• Study Type: observational
• Target: 88
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to determine whether there is a quantitative relationship between brain processes seen by a MRI and visual deficits caused by mild to moderate traumatic brain injuries (mTBI).

Conditions

TBI (Traumatic Brain Injury); Ocular Motility Disorders

Outcome Measures

Primary Outcomes (1)

• oculomotor performance

  Oculomotor performance will be measured with behavioral questionnaires, eye-charts, and computerized eye-tracking while subjects perform saccades and smooth pursuit motions.

  study enrollment / baseline

Secondary Outcomes (2)

• frontoparietal priority maps

  baseline

• white matter integrity

  baseline

Study Arms (2)

Control

no history of TBI or neurologic disorder

mTBI

documented past mild to moderate TBI

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants with mTBI who have previously participated in MRI studies; preference will be given to individuals with visual complaints such as blurred or double vision or headaches while reading. Participants with no history of TBI and no visual complaints will also be recruited into a control group.

You may qualify if:

• Normal or corrected to normal visual acuity
• No previously documented mTBI (target: 16 out of 88 participants invited for Visit 1)
• Previously documented mTBI (target: 72 out of 88 participants invited for Visit 1)
• Vision impairment (target: 48 out of 88 participants invited for Visit 1; expected to be comorbid with mTBI, but non-TBI participants with oculomotor impairments will not be excluded)

You may not qualify if:

• Current use of neuroactive drugs or medications
• Presence of neurological disorders (other than mTBI and mild PTSD)
• Contraindications for MRI (metal in the body, claustrophobia, diabetes or other diseases or drugs that affect thermoregulation)
• Inability to comply with behavioral task instructions

Sponsors & Collaborators

• University of Minnesota: lead

MeSH Terms

Conditions

Brain Injuries, Traumatic; Ocular Motility Disorders

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Cranial Nerve Diseases; Eye Diseases

Study Officials

• Cheryl A Olman, PhD

  University of Minnesota

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 22, 2014
• First Posted: September 26, 2014
• Study Start: July 1, 2015
• Primary Completion: February 1, 2018
• Study Completion: October 1, 2018
• Last Updated: March 21, 2019

Record last verified: 2019-03