Schizophrenia for "Life" - a Registry and Interview Study Among Elderly With Lifelong Schizophrenia

NCT02246283 | Completed

• 1 other identifier: Schizophrenia-Lifelong
• Study Type: observational
• Target: 10,404
• Locations: 1 country
• Sites: 1

Brief Summary

The elderly demographic is on the rise - and this includes elderly living with schizophrenia. Yet very little is known about their lives, how they cope with their condition and how it develops over time. Research in this patient-group is sparse; overall there seem to be a tendency for elderly patients to manifest fewer psychotic symptoms and experiencing an increase in the psychological quality of life with older age. Opinions are divided on the degree and extent to which this tendency reflects remission and/or recovery in older patients. In order to identify factors associated with a positive outcome we:

• Investigate the course and the outcomes of the illness over the lifespan, as well as the life course and outcomes.
• Investigate the current status of mental and physical health, quality of life as well as functional competence of elderly (55+ yr) with schizophrenia. Also the investigators \- Compare the trajectory and prognosis of schizophrenia (a chronic mental illness) with type 1 diabetes (a chronic somatic illness). This study will yield vital insights into how schizophrenia develops over time, isolating factors that determine how well patients fare. The perspective is to advance knowledge of elderly with schizophrenia with a view to optimizing and increasing the effectiveness of the interventions offered to this group.

Conditions

Schizophrenia

Keywords

schizophrenia; elderly; lifelong; quality of life; register; questionaire

Outcome Measures

Primary Outcomes (1)

• Ageing with schizophrenia

  Prognosis measured by use of healthcare system, use of medicine, co-morbidity, mortality, causes of mortality, and socio-demographic data, including highest level of education, years of employment/un-employment, use of health- and welfare services.

  up to 45 years

Secondary Outcomes (2)

• Quality of life

  1 month

• Remission

  6 months

Eligibility Criteria

• Age: 55 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Registry study: A nationwide register cohort study (1970-79) identifying psychiatric admissions (aged 18-40), who were registered with a schizophrenia diagnosis. Several Danish registers are applied. Interview study: A cross-sectional survey where 150 randomly drawn surviving members of the register cohort resident in the Region of Southern Denmark will be interviewed on the basis of internationally validated assessment tools.

You may qualify if:

• Initial schizophrenia diagnosis between the ages 18-40 (both incl) in the period 1970-1979 (both incl) Interview study: Residence in Region of Southern Denmark

You may not qualify if:

• Interview study: Mental retardation

Sponsors & Collaborators

• Kjeld Andersen: lead
• The Psychiatric Research Foundation in Southern Denmark: collaborator
• Region of Southern Denmark: collaborator
• University of Southern Denmark: collaborator
• The Danish Mental Health Foundation: collaborator
• The Danish Health Foundation (Helsefonden): collaborator
• The non-profit foundation Trygfonden.: collaborator
• Odense Patient Data Explorative Network: collaborator
• Jeppe Juhl and Ovita Juhls Memorial Grant: collaborator
• Butcher Max Wørzner and wife Inger Wørzner's Memorial Grant: collaborator

Study Sites (1)

Research Unit of Psychiatry, Psychiatric Unit Odense - University function

Odense C, 5000, Denmark

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Maria Brink, MD

  University of Southern Denmark

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 17, 2014
• First Posted: September 22, 2014
• Study Start: September 1, 2013
• Primary Completion: September 1, 2015
• Study Completion: December 1, 2017
• Last Updated: July 17, 2018

Record last verified: 2018-07

Locations

DK (1)