Hot Snare Versus Hot Snare Polypectomy With Saline Injection for Colorectal Polyps
HSPvsHSPASI
Hot Snare Polypectomy Vs. Hot Snare Polypectomy After Saline Injection for the Complete Resection of Neoplastic Colorectal Polyps: Prospective, Randomized Controlled Trial
1 other identifier
interventional
362
1 country
1
Brief Summary
The complete removal of colorectal polyp is required to prevent tumor recurrence and development of potential interval cancers. However, several studies have shown high incomplete resection rate in endoscopic removal of neoplastic colorectal polyps larger than 5 mm. The polypectomy techniques using hot snare are usually used for the removal of these polyps. However, the optimal technique for complete resection of these polyps is unknown. There are few data comparing hot snare polypectomy with hot snare polypectomy after saline injection for complete resection of colorectal polyps (5mm or larger). The aim of this study is to compare hot snare polypectomy with hot snare polypectomy after saline injection for removal of 5-10mm sized colorectal polyps.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jun 2014
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2014
CompletedFirst Submitted
Initial submission to the registry
September 10, 2014
CompletedFirst Posted
Study publicly available on registry
September 12, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2018
CompletedResults Posted
Study results publicly available
April 14, 2020
CompletedApril 14, 2020
April 1, 2020
3.5 years
September 10, 2014
July 17, 2019
April 6, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Complete Resection Rate
Complete resection was defined as the absence of residual polyp in the resection margin
2 weeks after
Secondary Outcomes (1)
Lateral Margin
2 weeks after
Study Arms (2)
Hot snare polypectomy
EXPERIMENTALIntervention: Procedure: removal of eligible polyps using hot snare polypectomy technique
Hot snare polypectomy(saline injection)
EXPERIMENTALIntervention: Procedure: removal of eligible polyps using hot snare polypectomy after saline injection technique
Interventions
hot snare polypectomy using electrosurgical snare with application of electrocautery for eligible polyps
hot snare polypectomy after saline injection using electrosurgical snare with application of electrocautery for eligible polyps
Eligibility Criteria
You may qualify if:
- Patients over the age of 30
- \~10mm sized colorectal polyps
- Informed consent
You may not qualify if:
- Inflammatory bowel diseases (Crohn's disease, or ulcerative colitis)
- Patient undergoing antiplatelets (aspirin, clopidogrel and others) or anticoagulant therapy
- ASA class III or more
- Any condition which, in the opinion of the Investigator, places the patient at unacceptable risk if he/she were to participate in the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Bo-In Leelead
- St Vincent's Hospitalcollaborator
- Incheon St.Mary's Hospitalcollaborator
Study Sites (1)
Division of Gastroenterology; Seoul St. Mary's hospital
Seoul, 137-701, South Korea
Related Publications (4)
Dwyer JP, Tan JYC, Urquhart P, Secomb R, Bunn C, Reynolds J, La Nauze R, Kemp W, Roberts S, Brown G. A prospective comparison of cold snare polypectomy using traditional or dedicated cold snares for the resection of small sessile colorectal polyps. Endosc Int Open. 2017 Nov;5(11):E1062-E1068. doi: 10.1055/s-0043-113564. Epub 2017 Oct 27.
PMID: 29250580BACKGROUNDKim JS, Lee BI, Choi H, Jun SY, Park ES, Park JM, Lee IS, Kim BW, Kim SW, Choi MG. Cold snare polypectomy versus cold forceps polypectomy for diminutive and small colorectal polyps: a randomized controlled trial. Gastrointest Endosc. 2015 Mar;81(3):741-7. doi: 10.1016/j.gie.2014.11.048.
PMID: 25708763BACKGROUNDKawamura T, Takeuchi Y, Asai S, Yokota I, Akamine E, Kato M, Akamatsu T, Tada K, Komeda Y, Iwatate M, Kawakami K, Nishikawa M, Watanabe D, Yamauchi A, Fukata N, Shimatani M, Ooi M, Fujita K, Sano Y, Kashida H, Hirose S, Iwagami H, Uedo N, Teramukai S, Tanaka K. A comparison of the resection rate for cold and hot snare polypectomy for 4-9 mm colorectal polyps: a multicentre randomised controlled trial (CRESCENT study). Gut. 2018 Nov;67(11):1950-1957. doi: 10.1136/gutjnl-2017-314215. Epub 2017 Sep 28.
PMID: 28970290BACKGROUNDKim SJ, Lee BI, Jung ES, Kim JS, Jun SY, Kim W, Ham H, Kim M, Lee SH, Lee HH, Park JM, Choi MG. Hot snare polypectomy versus endoscopic mucosal resection for small colorectal polyps: a randomized controlled trial. Surg Endosc. 2021 Sep;35(9):5096-5103. doi: 10.1007/s00464-020-07994-7. Epub 2020 Sep 28.
PMID: 32989532DERIVED
Results Point of Contact
- Title
- Bo-In Lee
- Organization
- Seoul ST. Mary's hospital
Study Officials
- PRINCIPAL INVESTIGATOR
Bo-In Lee
Seoul St. Mary's Hospital
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- MD, PhD
Study Record Dates
First Submitted
September 10, 2014
First Posted
September 12, 2014
Study Start
June 1, 2014
Primary Completion
December 1, 2017
Study Completion
February 1, 2018
Last Updated
April 14, 2020
Results First Posted
April 14, 2020
Record last verified: 2020-04
Data Sharing
- IPD Sharing
- Will not share