Detection of Brown Adipose Tissue by Magnetic Resonance Imaging

NCT02237872 | Completed

• 1 other identifier: 14-1980
• Study Type: observational
• Target: 8
• Locations: 1 country
• Sites: 2

Brief Summary

The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using \[18F\]-2-fluoro-2-deoxy-D-glucose (fluorodeoxyglucose) -PET as gold standard. In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed on a combined PET/MRI scanner under mild cold condition.

Conditions

Obesity; Brown Adipose Tissue

Keywords

Brown Adipose Tissue; MRI and PET detection of brown adipose tissue

Outcome Measures

Primary Outcomes (1)

• Average dice similarity coefficient

  The average dice similarity coefficient will be measured to assess the overlap between MRI and PET maps

  Up to 1 year after the imaging scan

Study Arms (1)

Healthy Volunteers

Healthy volunteers exposed to cold to activate brown fat

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy adult human with a BMI \<28

You may qualify if:

• Each subject must be fully informed and have signed consent.
• BMI \< 34
• Normal neurological and psychological development / able to give consent
• Willingness to participate in this study

You may not qualify if:

• Subjects less than 18 years of age
• Severe claustrophobia
• Women who are pregnant, nursing an infant or planning to become pregnant in the next 30 days
• People who have a condition that makes MRI unsafe for them (for example, cardiac pacemaker, epicardial pacemaker leads, cochlear implants, metal aneurysm clip, iron filings in your eyes or metal halo devices)
• Have had radiation therapy or chemotherapy in the 2 months prior to PET scan
• Subjects are taking medications that may interfere with BAT detection

Sponsors & Collaborators

• University of North Carolina, Chapel Hill: lead
• North Carolina Translational and Clinical Sciences Institute: collaborator

Study Sites (2)

Biomedical Research Imaging Center

Chapel Hill, North Carolina, 27599-7513, United States

Location

Biomedical Research Imaging Center

Chapel Hill, North Carolina, 27599, United States

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Rosa Tamara Branca, PhD

  University of North Carolina, Chapel Hill

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 9, 2014
• First Posted: September 11, 2014
• Study Start: January 20, 2015
• Primary Completion: August 27, 2015
• Study Completion: August 27, 2015
• Last Updated: October 1, 2025

Record last verified: 2025-08

Locations

US (2)