Serum CTRP3 and RBP4 Levels in Obesity and Hypertension

NCT02226471 | Completed DMC

• 1 other identifier: SW1000
• Study Type: observational
• Target: 2,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Insulin resistance is closely correlated with obesity and cardiovascular disease. Adipokines may play important roles in the pathogenesis of obesity, which are a link between obesity and obesity-related disorders.C1q/TNF-related protein-3 (CTRP3) and retinol-binding protein 4 (RBP4) are novel adipokine that modulates the action of insulin in various diseases. This study addressed the relationship between CTRP3, RBP4 and IR in newly diagnosed obesity and essential hypertension.

Conditions

Obesity; Hypertension

Outcome Measures

Primary Outcomes (1)

• CTRP3 and RBP4 levels were measured in obesity and hypertension

  531 subjects were required to fast overnight before the physical examination.Blood pressure was measured three times, each 2 min apart on the upper arm using a mercury sphygmomanometer in a seated, resting position after 10 minutes of rest; the mean of the three measurements was used for the statistical analysis.Weight, height and hip and waist circumference (WC), were measured. BMI was calculated as body weight in kilograms divided by the square of height (m2). WHR was calculated as the waist to hip circumference. Overnight fasting blood samples were collected in tubes containing liquid EDTA; the samples were centrifuged at -4°C and maintained at -80°C until assayed. FBG was assayed using the glucose oxidase method. UA, TC, TG, LDL-C and HDL-C concentrations were determined enzymatically.

  1 year

Study Arms (4)

NW-NBP group

normal weight and blood pressure subjects

NW-HTN group

Normal weight with hypertension subjects

OB-NBP group

obese-normal blood pressure subjects

OB-HTN group

Obese-hypertension subjects

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

We consecutively selected 2100 Chinese subjects from the general population who had undergone medical check-ups at the Southwest Hospital Medical Center at the Third Military Medical University

You may qualify if:

• Hypertension not taking antihypertensive medications
• Obesity not taking anti-obese or lipid-lowering medications

You may not qualify if:

• Heart failure;
• pregnant or lactating
• diabetes
• thyroid disease
• fractures
• osteoporosis
• tumors;

Sponsors & Collaborators

• Third Military Medical University: lead

Related Publications (1)

• Deng W, Li C, Zhang Y, Zhao J, Yang M, Tian M, Li L, Zheng Y, Chen B, Yang G. Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance. Diabetol Metab Syndr. 2015 Apr 10;7:33. doi: 10.1186/s13098-015-0029-0. eCollection 2015.

  PMID: 25878729 DERIVED

Related Links

• Implication of Progranulin and C1q/TNF-Related Protein-3 (CTRP3) on Inflammation and Atherosclerosis in Subjects with or without Metabolic Syndrome
• Identification of Adipokine Clusters Related to Parameters of Fat Mass, Insulin Sensitivity and Inflammation

MeSH Terms

Conditions

Obesity; Hypertension

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Deng Wuquan, PHD

  Southwest Hospital, China

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chongqing southwest hospital

Study Record Dates

• First Submitted: August 24, 2014
• First Posted: August 27, 2014
• Study Start: March 1, 2012
• Primary Completion: February 1, 2014
• Study Completion: February 1, 2014
• Last Updated: August 27, 2014

Record last verified: 2014-08