Exercise Improve Sympathetic Modulation in Chronic Heart Failure Patients
Exercise Training Improves Oscillatory Pattern and Arterial Baroreflex Control of Sympathetic Nerve Activity in Patients With Chronic Heart Failure
1 other identifier
interventional
26
1 country
1
Brief Summary
The purpose of this study is to verify the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_4
Started Aug 2013
Shorter than P25 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2014
CompletedFirst Submitted
Initial submission to the registry
August 4, 2014
CompletedFirst Posted
Study publicly available on registry
August 19, 2014
CompletedAugust 19, 2014
August 1, 2014
8 months
August 4, 2014
August 18, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Autonomic control
To asses the effects of exercise training on sympathetic modulation by analyze of autonomic control in chronic heart failure patients after 4 months protocol.Time series of muscle sympathetic nerve activity and systolic arterial pressure were analyzed by autoregressive spectral analysis
4 months
Secondary Outcomes (1)
Arterial baroreflex control
4 months
Study Arms (1)
exercise training
EXPERIMENTALWe studied twenty-six chronic heart failure outpatients and they were assigned to 2 groups: Untrained (n=13) and trained (n=13).
Interventions
Eligibility Criteria
You may qualify if:
- Patients with chronic heart failure
- Age 30 to 70 years
- Functional class II to III of New York Heart Association
- Left ventricular ejection fraction (LVEF) ≤40%
- Peak oxygen uptake (VO2) ≤20
You may not qualify if:
- Recent myocardial infarction or unstable angina (\<3 months)
- heart failure duration (\<3 months)
- Permanent pacemaker dependence
- Atrial fibrillation
- Skeletal muscle abnormality (e.g., arthritis)
- Participation in a regular exercise program
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Sao Paulo General Hospitallead
- InCor Heart Institutecollaborator
Study Sites (1)
Instituto do Coração - HC/FMUSP
São Paulo, São Paulo, 05403-900, Brazil
Related Publications (1)
Groehs RV, Toschi-Dias E, Antunes-Correa LM, Trevizan PF, Rondon MU, Oliveira P, Alves MJ, Almeida DR, Middlekauff HR, Negrao CE. Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients. Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1096-102. doi: 10.1152/ajpheart.00723.2014. Epub 2015 Mar 6.
PMID: 25747752DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Heart Institute HC/FMUSP, HC/FMUSP
Heart Institute, University of Sao Paulo
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- NA
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD student
Study Record Dates
First Submitted
August 4, 2014
First Posted
August 19, 2014
Study Start
August 1, 2013
Primary Completion
April 1, 2014
Study Completion
July 1, 2014
Last Updated
August 19, 2014
Record last verified: 2014-08