NCT00477789

Brief Summary

In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 23, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 24, 2007

Completed
Last Updated

May 24, 2007

Status Verified

May 1, 2007

First QC Date

May 23, 2007

Last Update Submit

May 23, 2007

Conditions

Chronic Heart Failure

Keywords

chronic heart failurediastolic dysfunctionuric acid

Outcome Measures

Primary Outcomes (1)

  • diastolic function uric acid levels BNP

    three months

Interventions

allopurinolDRUG

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • chronic heart failure;
  • left ventricular systolic dysfunction (ejection fraction \<45%)
  • stable clinical conditions in the previous three months
  • optimal medical therapy for CHF
  • normal sinus rhythm
  • written informed consent
  • age \>18 years

You may not qualify if:

  • renal failure (s-creatinine \>2.5 mg/dl)
  • already on allopurinol
  • malignancies
  • chronic inflammatory diseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Division of Cardiology, University Hospital of Verona

Verona, 37129, Italy

Location

MeSH Terms

Interventions

Allopurinol

Intervention Hierarchy (Ancestors)

PurinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Officials

  • Mariantonietta Cicoira, MD, PhD

    Division of Cardiology, University of Verona, Italy

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 23, 2007

First Posted

May 24, 2007

Last Updated

May 24, 2007

Record last verified: 2007-05

Locations

IT(1)