Effects of Disrupting Prolonged Sitting With Different Physical Activity Protocols on Metabolic Risk Factors in Sedentary Adults

NCT02215603 | Unknown

• 1 other identifier: ProlongedSitting
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Great controversy exists with respect to the optimal or the minimum volume, intensity, and frequency of physical activity capable of attenuating the hazards of prolonged sitting on the metabolic profile. Thus, our study aims to comprehensively investigate the effects of disrupting prolonged sitting with different physical activity protocols on metabolic risk factors in sedentary males. Ten sedentary males will take part in this randomized cross-over trial consisting of four 27-h conditions. All conditions will be identical except for the physical activity: prolonged sitting intervention (SIT) participants will sit continuously for 9 hours; prolonged sitting+interval standing intervention (STAND), participants will stand for 15 min every 30 minutes (total 270 min) during the 9 hours of sitting; prolonged sitting+moderate-intensity exercise bout (MVPA) participants will perform a 30-min moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they will sit for the remaining time; and prolonged sitting+moderate-intensity exercise bout +interval standing intervention (MVPA-STAND), participants will perform a 30-min moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they will stand for 15 min every 30 minutes (total 240 min) during the remaining 8 hours of sitting. Blood glucose, insulin, lipids and cytokines will be determined. The investigators expect that disrupting prolonged sitting with intermittent standing and a moderate-exercise bout will positively affect the metabolic profile of the participants. Furthermore, we will investigate if combined, these strategies will have an additive effect.

Conditions

Prolonged Sitting; Breaking Prolonged Sitting With Physical Activity

Outcome Measures

Primary Outcomes (1)

• Area under the curve of glucose and insulin postprandial responses

  Glucose and insulin levels will be assessed 10 min before, and 30, 60, 120 and 180 min after each main meal. These postprandial responses will be defined as the area under the curve (AUC) assessed over the 3-h period after each main meal (3-h AUC) and the cumulative AUC after all main meals (12-h AUC).

  27 h

Secondary Outcomes (2)

• Glucose levels

  27 hours

• Area under the curve of lipid postprandial responses

  27 h

Other Outcomes (1)

• Area under the curve of cytokine postprandial responses

  27 h

Study Arms (4)

Prolonged sitting

NO INTERVENTION

9 h of prolonged sitting

Prolonged sitting + interval standing bouts

EXPERIMENTAL

Stand bout for 15-min every 30 minutes during the 9 hours of sitting

Behavioral: Breaking prolonged sitting with physical activity

Moderate exercise bout + Prolonged sitting

EXPERIMENTAL

30-min moderate-intensity exercise bout followed by 8 h of sitting

Behavioral: Breaking prolonged sitting with physical activity

Moderate exercise bout + Prolonged sitting +Standing bouts

EXPERIMENTAL

30-min moderate-intensity exercise bout and stand bout for 15-min every 30 minutes during the remaining 8 hours of sitting

Behavioral: Breaking prolonged sitting with physical activity

Interventions

Breaking prolonged sitting with physical activity BEHAVIORAL

Moderate exercise bout + Prolonged sitting; Moderate exercise bout + Prolonged sitting +Standing bouts; Prolonged sitting + interval standing bouts

Eligibility Criteria

• Age: 25 Years - 55 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Males,
• age 25-55 y,
• BMI \>18 and \<35 kg/m2

You may not qualify if:

• Clinically diagnosed diabetes,
• dyslipidaemia,
• hypertension,
• use of glucose- and/or lipid-lowering medication,
• smoking,
• evidence of thyroid, liver, lung, heart or kidney disease,
• non-sedentary occupation and primary means of commuting to work (i.e., cycling) in the last 4 months,
• VO2max levels above the considered average fitness according to age,
• contraindication to increased levels of physical activity.

Sponsors & Collaborators

• Rigshospitalet, Denmark: lead
• Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.: collaborator

Study Sites (1)

Centre of Inflammation and Metabolism

Copenhagen, 2100, Denmark

RECRUITING

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Fabiana Benatti

CONTACT

+45 35450898; fabiana.braga.benatti@regionh.dk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: August 7, 2014
• First Posted: August 13, 2014
• Study Start: August 1, 2014
• Primary Completion: June 1, 2016
• Study Completion: December 1, 2016
• Last Updated: January 13, 2016

Record last verified: 2016-01

Locations

DK (1)