High Flow Nasal Canula Oxygen Helps Preoxygenate ARDS Patients

NCT02214576 | Completed

• 1 other identifier: HLM_JDR2
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Tracheal intubation in the ICU is associated with significant complications and morbidity. Desaturation is among the most frequent and hazardous complication, occurring in almost one out of four intubations, that may in some instances lead to cardiac arrest; despite appropriate preoxygenation. Non-invasive ventilation may help improve preoxygenation but does not allow for apneic oxygenation and may not be performed in patients with neurological impairment. High flow nasal canula oxygen is increasingly used in the ICU in patients with acute hypoxemic respiratory failure and may be used to improve preoxygenation. It is currently used in our ICU for that purpose. Because high flow nasal canula oxygen is our first line oxyten therapy for patients with acute respirtory distress syndrome, we sought to determine its use as a means to ensure preoxygenation in those ARDS patients that require intubation.

Conditions

Acute Respiratory Distress Syndrome

Keywords

Respiratory Distress Syndrome, Adult; intubation, intratracheal; Oxygen Inhalation Therapy; Positive-Pressure Respiration; laryngoscopy

Outcome Measures

Primary Outcomes (1)

• Oxygen saturation

  oxygen saturation measured by pulse oxymetry during intubation and compared to levels before intubation

  30 minutes

Secondary Outcomes (1)

• complications

  60 minutes

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

acute respiratory distress syndrome patients that require tracheal intubation in the ICU

You may qualify if:

• ARDS according to the Berlin criteria
• use of high flow nasal canula oxygen

Sponsors & Collaborators

• Hôpital Louis Mourier: lead

Study Sites (1)

Medico-surgical ICU, Louis Mourier Hospital

Colombes, 92700, France

Location

Related Publications (4)

• Ricard JD. High flow nasal oxygen in acute respiratory failure. Minerva Anestesiol. 2012 Jul;78(7):836-41. Epub 2012 Apr 24.

  PMID: 22531566 BACKGROUND

• Sztrymf B, Messika J, Bertrand F, Hurel D, Leon R, Dreyfuss D, Ricard JD. Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Intensive Care Med. 2011 Nov;37(11):1780-6. doi: 10.1007/s00134-011-2354-6. Epub 2011 Sep 27.

  PMID: 21946925 BACKGROUND

• Sztrymf B, Messika J, Mayot T, Lenglet H, Dreyfuss D, Ricard JD. Impact of high-flow nasal cannula oxygen therapy on intensive care unit patients with acute respiratory failure: a prospective observational study. J Crit Care. 2012 Jun;27(3):324.e9-13. doi: 10.1016/j.jcrc.2011.07.075. Epub 2011 Sep 29.

  PMID: 21958974 BACKGROUND

• Messika J, Ben Ahmed K, Gaudry S, Miguel-Montanes R, Rafat C, Sztrymf B, Dreyfuss D, Ricard JD. Use of High-Flow Nasal Cannula Oxygen Therapy in Subjects With ARDS: A 1-Year Observational Study. Respir Care. 2015 Feb;60(2):162-9. doi: 10.4187/respcare.03423. Epub 2014 Nov 4.

  PMID: 25371400 BACKGROUND

MeSH Terms

Conditions

Respiratory Distress Syndrome

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Study Officials

• Jean-Damien RICARD, MD, PhD

  University Paris Diderot and Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Intensive Care Medicine, Assistant-head of ICU

Study Record Dates

• First Submitted: August 11, 2014
• First Posted: August 12, 2014
• Study Start: September 1, 2011
• Primary Completion: August 1, 2015
• Study Completion: August 1, 2015
• Last Updated: August 14, 2015

Record last verified: 2015-08

Locations

FR (1)