CENTER-TBI: Collaborative European NeuroTrauma Effectiveness Research in TBI

NCT02210221 | Completed Results DMC

• 1 other identifier: 602150
• Study Type: observational
• Target: 4,559
• Locations: 18 countries
• Sites: 63

Brief Summary

The research aims of the CENTER-TBI study are to:

1. 1.better characterize Traumatic Brain Injury (TBI) as a disease and describe it in a European context, and
2. 2.identify the most effective clinical interventions for managing TBI.
3. 3.To collect high quality clinical and epidemiological data with repositories for neuro-imaging, DNA, and serum from patients with TBI.
4. 4.To refine and improve outcome assessment and develop health utility indices for TBI.
5. 5.To develop multidimensional approaches to characterisation and prediction of TBI.
6. 6.To define patient profiles which predict efficacy of specific interventions ("Precision Medicine").
7. 7.To develop performance indicators for quality assurance and quality improvement in TBI care.
8. 8.To validate the common data elements (CDEs) for broader use in international settings, and to develop a user-friendly web based data entry instrument and case report form builder.
9. 9.To develop an open database compatible with Federal Interagency Traumatic Brain Injury Research (FITBIR).
10. 10.To intensify networking activities and international collaborations in TBI.
11. 11.To disseminate study results and management recommendations for TBI to health care professionals, policy makers and consumers, aiming to improve health care for TBI at individual and population levels.
12. 12.To develop a "knowledge commons" for TBI, integrating CENTER-TBI outputs into systematic reviews.

Conditions

Traumatic Brain Injury

Keywords

TBI

Outcome Measures

Primary Outcomes (3)

• Glasgow Outcome Scale - Extended (GOSE) at 6 Months

  The Extended Glasgow Outcome Scale is a global scale for functional outcome that rates patient status into 8 categories, going from dead to good recovery. 1. Death 2. Vegetative sate 3. Lower severe disability 4. Upper severe disability 5. Lower moderate disability 6. Upper moderate disability - some disability but can potentially return to some form of employment 7. Lower good recovery - minor physical or mental defect 8. Upper good recovery - full recovery The 6-month GOSE score is available in 3804 patients (84%).

  6 months

• SF-12v2 Health Survey (Short-Form Health Survey With 12 Questions) at 6 Months

  The SF-12v2 Health Survey uses 12 questions to measure functional health and well-being from the patient's point of view. The SF-12v2 at 6 months is available in 2300 patients.

  6 months

• 6 Month Quality of Life in Brain Injury (Qolibri-OS) <52 (Impaired)

  The Quality of Life in Brain Injury (Qolibri-OS) is a 6 item overall scale that provides a profile of health-related quality of life in domains typicality affected by brain injury, such as physical function, cognition, emotional status, ability to perform daily activities, personal life and social relationship, and satisfaction with current situation and future prospects. The QOLIBRI scores are reported on a 0-100 scale , where 0=worst possible quality of life and 100=best possible quality of life.

  6 months

Secondary Outcomes (15)

• 6 Month Post-traumatic Stress Disorder (PTSD) Checklist for DSM-5 (PCL-5) <33 (Impaired)

  6 months

• 6 Month Rivermead Post Concussion Questionnaire <16 (Impaired)

  6 months

• 6 Month Galveston Orientation and Amnesia Test (GOAT) < 75 (Impaired)

  6 months

• 6 Month Rey Auditory Verbal Learning Test (RAVLT) - Impaired

  6 months

• 6 Month Timed up and go Test - Impaired

  6 months

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients presenting with traumatic brain injury. The data collection will be stratified upon enrolment into 3 clinical groups differentiated by clinical care path: * ER stratum: patients seen and discharged from the ER * Admission stratum: patients admitted to hospital but not to the ICU * ICU stratum: patients admitted directly to the ICU

You may qualify if:

• Clinical diagnosis of TBI
• Clinical indication for CT scan
• Presentation within 24 hours of injury
• Informed consent obtained according to local and national requirements

You may not qualify if:

• Severe pre-existing neurological disorder that would confound outcome assessments

Sponsors & Collaborators

• University Hospital, Antwerp: lead
• University of Cambridge: collaborator
• Erasmus Medical Center: collaborator
• San Gerardo Hospital: collaborator
• University of Sheffield: collaborator
• University of California, San Francisco: collaborator
• Karolinska Institutet: collaborator
• ICON plc: collaborator
• GABO:mi: collaborator
• icometrix: collaborator

Study Sites (65)

Innsbruck Medical University

Innsbruck, Austria

Location

Medical University Vienna

Vienna, Austria

Location

Antwerp University Hospital

Edegem, Belgium

Location

University Hospitals Leuven

Leuven, Belgium

Location

CHR Citadelle

Liège, Belgium

Location

CHU Liege

Liège, Belgium

Location

Region Hovedstaden Rigshospitalet

Copenhagen, Denmark

Location

Odense University Hospital

Odense, Denmark

Location

Helsinki University Central Hospital

Helsinki, Finland

Location

Turku University Hospital

Turku, Finland

Location

University Hospital of Grenoble

Grenoble, France

Location

Lille University Hospital

Lille, France

Location

University Hospital Nancy

Nancy, France

Location

APHP

Paris, France

Location

CHU Poitiers

Poitiers, France

Location

University Hospital Aachen

Aachen, Germany

Location

Charité Campus Virchow

Berlin, Germany

Location

University Hospital Heidelberg

Heidelberg, Germany

Location

Klinikum Ludwigsburg

Ludwigsburg, Germany

Location

University of Pecs

Pécs, Hungary

Location

University of Szeged

Szeged, Hungary

Location

Rambam Medical Center

Haifa, Israel

Location

Hadassah-hebrew University Medical Center

Jerusalem, Israel

Location

Bufalini Hospital

Cesena, Italy

Location

Fondazione IRCCS Cà Granda Ospedale Maggiore Poloclinico

Milan, Italy

Location

Niguarda Hospital

Milan, Italy

Location

S Raffaele University Hospital

Milan, Italy

Location

ASST di Monza

Monza, Italy

Location

Maggiore Della Carità Hospital

Novara, Italy

Location

Azienda Ospedaliera Università di Padova

Padua, Italy

Location

AOU Città della Salute e della Scienza di Torino

Torino, Italy

Location

Rezekne Hospital

Rēzekne, Latvia

Location

Pauls Stradins Clinical University Hospital

Riga, Latvia

Location

Riga Eastern Clinical University Hospital

Riga, Latvia

Location

University of Health Sciences

Kaunas, Lithuania

Location

Center of neurovascular surgery, Clinic of neurology and neurosurgery, Vilnius University

Vilnius, Lithuania

Location

Kaunas University of technology and Vilnius University

Vilnius, Lithuania

Location

University Medical Center Groningen

Groningen, Netherlands

Location

Leiden University Medical Center

Leiden, Netherlands

Location

Radboud University Medical Center

Nijmegen, Netherlands

Location

Erasmus MC

Rotterdam, Netherlands

Location

Medical Center Haaglanden

The Hague, Netherlands

Location

The HAGA Hospital

The Hague, Netherlands

Location

TweeSteden Ziekenhuis

Tilburg, Netherlands

Location

Oslo University Hospital

Oslo, Norway

Location

University Hospital Northern Norway

Tromsø, Norway

Location

St Olavs Hospital/Norwegian University of science and technology

Trondheim, Norway

Location

Emergency County Hospital Timisoara

Timișoara, Romania

Location

Clinical centre of Vojvodina

Novi Sad, Serbia

Location

Vall d'Hebron University Hospital

Barcelona, Spain

Location

Cruces University Hospital

Bilbao, Spain

Location

Hospital Universitario 12 de Octubre

Madrid, Spain

Location

Clínico Universitario de Valencia

Valencia, Spain

Location

Karolinska University Hospital

Stockholm, Sweden

Location

Umea University Hospital

Umeå, Sweden

Location

Centre Hospitalier Universitaire Vaudois

Lausanne, Switzerland

Location

Queen Elizabeth Hospital

Birmingham, United Kingdom

Location

Southmead Hospital

Bristol, United Kingdom

Location

Addenbrookes Hospital

Cambridge, United Kingdom

Location

Lothian Health Board

Edinburgh, United Kingdom

Location

The Walton centre NHS Foundation Trust

Liverpool, United Kingdom

Location

Kings college London

London, United Kingdom

Location

Salford Royal Hospital

Salford, United Kingdom

Location

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, United Kingdom

Location

University Hospitals Southampton NHS Trust

Southampton, United Kingdom

Location

Related Publications (32)

• Jacob L, Castro J, Heslot C, Andelic N, Tenovuo O; CENTER-TBI Participants and Investigators (Appendix); Azouvi P. Absence from work in the 12 months following mild traumatic brain injury in Europe: a CENTER-TBI cohort study. Ann Phys Rehabil Med. 2025 Nov;68(8):102017. doi: 10.1016/j.rehab.2025.102017. Epub 2025 Sep 30.

  PMID: 41032948 DERIVED

• Kals M, Wilson L, Levey DF, Parodi L, Steyerberg EW, Richardson S, He F, Sun X, Jain S, Palotie A, Ripatti S, Rosand J, Manley GT, Maas AIR, Stein MB, Menon DK; Genetic Associations In Neurotrauma (GAIN) Consortium (with contribution from the CENTER-TBI and TRACK-TBI studies). Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts. EClinicalMedicine. 2024 Dec 5;78:102956. doi: 10.1016/j.eclinm.2024.102956. eCollection 2024 Dec.

  PMID: 39720422 DERIVED

• Guglielmi A, Graziano F, Bogossian EG, Turgeon AF, Taccone FS, Citerio G; CENTER-TBI Participants and Investigators. Haemoglobin values, transfusion practices, and long-term outcomes in critically ill patients with traumatic brain injury: a secondary analysis of CENTER-TBI. Crit Care. 2024 Jun 14;28(1):199. doi: 10.1186/s13054-024-04980-6.

  PMID: 38877571 DERIVED

• Pisica D, Volovici V, Yue JK, van Essen TA, den Boogert HF, Vande Vyvere T, Haitsma I, Nieboer D, Markowitz AJ, Yuh EL, Steyerberg EW, Peul WC, Dirven CMF, Menon DK, Manley GT, Maas AIR, Lingsma HF; CENTER-TBI Participants and Investigators. Clinical and Imaging Characteristics, Care Pathways, and Outcomes of Traumatic Epidural Hematomas: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study. Neurosurgery. 2024 Nov 1;95(5):986-999. doi: 10.1227/neu.0000000000002982. Epub 2024 May 21.

  PMID: 38771081 DERIVED

• Vreeburg RJG, Singh RD, van Erp IAM, Korhonen TK, Yue JK, Mee H, Timofeev I, Kolias A, Helmy A, Depreitere B, Moojen WA, Younsi A, Hutchinson P, Manley GT, Steyerberg EW, de Ruiter GCW, Maas AIR, Peul WC, van Dijck JTJM, den Boogert HF, Posti JP, van Essen TA; for the CENTER-TBI Participants and Investigators. Early versus delayed cranioplasty after decompressive craniectomy in traumatic brain injury: a multicenter observational study within CENTER-TBI and Net-QuRe. J Neurosurg. 2024 Apr 26;141(4):895-907. doi: 10.3171/2024.1.JNS232172. Print 2024 Oct 1.

  PMID: 38669706 DERIVED

• Howe EI, Andelic N, Brunborg C, Zeldovich M, Helseth E, Skandsen T, Olsen A, Fure SCR, Theadom A, Rauen K, Madsen BA, Jacobs B, van der Naalt J, Tartaglia MC, Einarsen CE, Storvig G, Tronvik E, Tverdal C, von Steinbuchel N, Roe C, Hellstrom T; CENTER-TBI Participants and Investigators. Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI. J Headache Pain. 2024 Mar 25;25(1):44. doi: 10.1186/s10194-024-01751-0.

  PMID: 38528477 DERIVED

• Zeldovich M, Bockhop F, Covic A, Mueller I, Polinder S, Mikolic A, van der Vlegel M, von Steinbuechel N; CENTER-TBI participants and investigators. Factorial validity and comparability of the six translations of the Rivermead Post-Concussion Symptoms Questionnaire translations: results from the CENTER-TBI study. J Patient Rep Outcomes. 2023 Sep 8;7(1):90. doi: 10.1186/s41687-023-00632-5.

  PMID: 37682406 DERIVED

• van Essen TA, van Erp IAM, Lingsma HF, Pisica D, Yue JK, Singh RD, van Dijck JTJM, Volovici V, Younsi A, Kolias A, Peppel LD, Heijenbrok-Kal M, Ribbers GM, Menon DK, Hutchinson PJA, Manley GT, Depreitere B, Steyerberg EW, Maas AIR, de Ruiter GCW, Peul WC; CENTER-TBI Investigators and Participants. Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study. EClinicalMedicine. 2023 Aug 9;63:102161. doi: 10.1016/j.eclinm.2023.102161. eCollection 2023 Sep.

  PMID: 37600483 DERIVED

• Lang L, Wang T, Xie L, Yang C, Skudder-Hill L, Jiang J, Gao G, Feng J. An independently validated nomogram for individualised estimation of short-term mortality risk among patients with severe traumatic brain injury: a modelling analysis of the CENTER-TBI China Registry Study. EClinicalMedicine. 2023 Apr 28;59:101975. doi: 10.1016/j.eclinm.2023.101975. eCollection 2023 May.

  PMID: 37180469 DERIVED

• Howe EI, Zeldovich M, Andelic N, von Steinbuechel N, Fure SCR, Borgen IMH, Forslund MV, Hellstrom T, Soberg HL, Sveen U, Rasmussen M, Kleffelgaard I, Tverdal C, Helseth E, Lovstad M, Lu J, Arango-Lasprilla JC, Tenovuo O, Azouvi P, Dawes H, Roe C; CENTER-TBI participants and investigators. Rehabilitation and outcomes after complicated vs uncomplicated mild TBI: results from the CENTER-TBI study. BMC Health Serv Res. 2022 Dec 16;22(1):1536. doi: 10.1186/s12913-022-08908-0.

  PMID: 36527074 DERIVED

• Rezoagli E, Petrosino M, Rebora P, Menon DK, Mondello S, Cooper DJ, Maas AIR, Wiegers EJA, Galimberti S, Citerio G; CENTER-TBI, OzENTER-TBI Participants and Investigators. High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI. Intensive Care Med. 2022 Dec;48(12):1709-1725. doi: 10.1007/s00134-022-06884-x. Epub 2022 Oct 20.

  PMID: 36264365 DERIVED

• Akerlund CAI, Holst A, Stocchetti N, Steyerberg EW, Menon DK, Ercole A, Nelson DW; CENTER-TBI Participants and Investigators. Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study. Crit Care. 2022 Jul 27;26(1):228. doi: 10.1186/s13054-022-04079-w.

  PMID: 35897070 DERIVED

• Volovici V, Pisica D, Gravesteijn BY, Dirven CMF, Steyerberg EW, Ercole A, Stocchetti N, Nelson D, Menon DK, Citerio G, van der Jagt M, Maas AIR, Haitsma IK, Lingsma HF; CENTER-TBI investigators, participants for the ICU stratum. Comparative effectiveness of intracranial hypertension management guided by ventricular versus intraparenchymal pressure monitoring: a CENTER-TBI study. Acta Neurochir (Wien). 2022 Jul;164(7):1693-1705. doi: 10.1007/s00701-022-05257-z. Epub 2022 Jun 1.

  PMID: 35648213 DERIVED

• van Essen TA, Lingsma HF, Pisica D, Singh RD, Volovici V, den Boogert HF, Younsi A, Peppel LD, Heijenbrok-Kal MH, Ribbers GM, Walchenbach R, Menon DK, Hutchinson P, Depreitere B, Steyerberg EW, Maas AIR, de Ruiter GCW, Peul WC; CENTER-TBI Collaboration Group. Surgery versus conservative treatment for traumatic acute subdural haematoma: a prospective, multicentre, observational, comparative effectiveness study. Lancet Neurol. 2022 Jul;21(7):620-631. doi: 10.1016/S1474-4422(22)00166-1. Epub 2022 May 5.

  PMID: 35526554 DERIVED

• Holthe IL, Dahl HM, Rohrer-Baumgartner N, Eichler S, Elseth MF, Holthe O, Berntsen T, Yeates KO, Andelic N, Lovstad M. Neuropsychological Impairment, Brain Injury Symptoms, and Health-Related Quality of Life After Pediatric TBI in Oslo. Front Neurol. 2022 Jan 28;12:719915. doi: 10.3389/fneur.2021.719915. eCollection 2021.

  PMID: 35153967 DERIVED

• Huijben JA, Pisica D, Ceyisakar I, Stocchetti N, Citerio G, Maas AIR, Steyerberg EW, Menon DK, van der Jagt M, Lingsma HF. Pharmaceutical Venous Thrombosis Prophylaxis in Critically Ill Traumatic Brain Injury Patients. Neurotrauma Rep. 2022 Jan 7;2(1):4-14. doi: 10.1089/neur.2021.0037. eCollection 2022.

  PMID: 35112104 DERIVED

• Galimberti S, Graziano F, Maas AIR, Isernia G, Lecky F, Jain S, Sun X, Gardner RC, Taylor SR, Markowitz AJ, Manley GT, Valsecchi MG, Bellelli G, Citerio G; CENTER-TBI and TRACK-TBI participants and investigators. Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation. Lancet Neurol. 2022 Feb;21(2):153-162. doi: 10.1016/S1474-4422(21)00374-4.

  PMID: 35065038 DERIVED

• Puybasset L, Perlbarg V, Unrug J, Cassereau D, Galanaud D, Torkomian G, Battisti V, Lefort M, Velly L, Degos V, Citerio G, Bayen E, Pelegrini-Issac M; MRI-COMA Investigators CENTER-TBI MRI Participants and MRI Only Investigators. Prognostic value of global deep white matter DTI metrics for 1-year outcome prediction in ICU traumatic brain injury patients: an MRI-COMA and CENTER-TBI combined study. Intensive Care Med. 2022 Feb;48(2):201-212. doi: 10.1007/s00134-021-06583-z. Epub 2022 Dec 14.

  PMID: 34904191 DERIVED

• Citerio G, Robba C, Rebora P, Petrosino M, Rossi E, Malgeri L, Stocchetti N, Galimberti S, Menon DK; Center-TBI participants and investigators. Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study. Intensive Care Med. 2021 Sep;47(9):961-973. doi: 10.1007/s00134-021-06470-7. Epub 2021 Jul 24.

  PMID: 34302517 DERIVED

• Robba C, Rebora P, Meyfroidt G, Citerio G. The authors reply. Crit Care Med. 2021 May 1;49(5):e554-e555. doi: 10.1097/CCM.0000000000004961. No abstract available.

  PMID: 33854024 DERIVED

• Huijben JA, Dixit A, Stocchetti N, Maas AIR, Lingsma HF, van der Jagt M, Nelson D, Citerio G, Wilson L, Menon DK, Ercole A; CENTER-TBI investigators and participants. Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis. Crit Care. 2021 Feb 23;25(1):78. doi: 10.1186/s13054-020-03370-y.

  PMID: 33622371 DERIVED

• Borgen IMH, Roe C, Brunborg C, Tenovuo O, Azouvi P, Dawes H, Majdan M, Ranta J, Rusnak M, Wiegers EJA, Tverdal C, Jacob L, Cogne M, von Steinbuechel N, Andelic N; CENTER-TBI participants investigators. Care transitions in the first 6months following traumatic brain injury: Lessons from the CENTER-TBI study. Ann Phys Rehabil Med. 2021 Nov;64(6):101458. doi: 10.1016/j.rehab.2020.10.009. Epub 2021 Jul 23.

  PMID: 33246186 DERIVED

• Robba C, Banzato E, Rebora P, Iaquaniello C, Huang CY, Wiegers EJA, Meyfroidt G, Citerio G; Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) ICU Participants and Investigators. Acute Kidney Injury in Traumatic Brain Injury Patients: Results From the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study. Crit Care Med. 2021 Jan 1;49(1):112-126. doi: 10.1097/CCM.0000000000004673.

  PMID: 33060506 DERIVED

• Gravesteijn BY, Sewalt CA, Nieboer D, Menon DK, Maas A, Lecky F, Klimek M, Lingsma HF; CENTER-TBI collaborators. Tracheal intubation in traumatic brain injury: a multicentre prospective observational study. Br J Anaesth. 2020 Oct;125(4):505-517. doi: 10.1016/j.bja.2020.05.067. Epub 2020 Jul 31.

  PMID: 32747075 DERIVED

• Gao G, Wu X, Feng J, Hui J, Mao Q, Lecky F, Lingsma H, Maas AIR, Jiang J; China CENTER-TBI Registry Participants. Clinical characteristics and outcomes in patients with traumatic brain injury in China: a prospective, multicentre, longitudinal, observational study. Lancet Neurol. 2020 Aug;19(8):670-677. doi: 10.1016/S1474-4422(20)30182-4.

  PMID: 32702336 DERIVED

• Robba C, Rebora P, Banzato E, Wiegers EJA, Stocchetti N, Menon DK, Citerio G; Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Participants and Investigators. Incidence, Risk Factors, and Effects on Outcome of Ventilator-Associated Pneumonia in Patients With Traumatic Brain Injury: Analysis of a Large, Multicenter, Prospective, Observational Longitudinal Study. Chest. 2020 Dec;158(6):2292-2303. doi: 10.1016/j.chest.2020.06.064. Epub 2020 Jul 4.

  PMID: 32634435 DERIVED

• Riemann L, Beqiri E, Smielewski P, Czosnyka M, Stocchetti N, Sakowitz O, Zweckberger K, Unterberg A, Younsi A; CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators. Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury: a CENTER-TBI study. Crit Care. 2020 May 26;24(1):266. doi: 10.1186/s13054-020-02974-8.

  PMID: 32456684 DERIVED

• Gravesteijn BY, Nieboer D, Ercole A, Lingsma HF, Nelson D, van Calster B, Steyerberg EW; CENTER-TBI collaborators. Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury. J Clin Epidemiol. 2020 Jun;122:95-107. doi: 10.1016/j.jclinepi.2020.03.005. Epub 2020 Mar 20.

  PMID: 32201256 DERIVED

• Huijben JA, Wiegers EJA, Ercole A, de Keizer NF, Maas AIR, Steyerberg EW, Citerio G, Wilson L, Polinder S, Nieboer D, Menon D, Lingsma HF, van der Jagt M; CENTER-TBI investigators and participants for the ICU stratum. Quality indicators for patients with traumatic brain injury in European intensive care units: a CENTER-TBI study. Crit Care. 2020 Mar 4;24(1):78. doi: 10.1186/s13054-020-2791-0.

  PMID: 32131882 DERIVED

• Van Essen TA, Volovici V, Cnossen MC, Kolias A, Ceyisakar I, Nieboer D, Peppel LD, Heijenbrok-Kal M, Ribbers G, Menon D, Hutchinson P, Depreitere B, de Ruiter GCW, Lingsma HF, Steyerberg EW, Maas AI, Peul WC. Comparative effectiveness of surgery in traumatic acute subdural and intracerebral haematoma: study protocol for a prospective observational study within CENTER-TBI and Net-QuRe. BMJ Open. 2019 Oct 16;9(10):e033513. doi: 10.1136/bmjopen-2019-033513.

  PMID: 31619435 DERIVED

• Steyerberg EW, Wiegers E, Sewalt C, Buki A, Citerio G, De Keyser V, Ercole A, Kunzmann K, Lanyon L, Lecky F, Lingsma H, Manley G, Nelson D, Peul W, Stocchetti N, von Steinbuchel N, Vande Vyvere T, Verheyden J, Wilson L, Maas AIR, Menon DK; CENTER-TBI Participants and Investigators. Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study. Lancet Neurol. 2019 Oct;18(10):923-934. doi: 10.1016/S1474-4422(19)30232-7.

  PMID: 31526754 DERIVED

• Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A; CENTER-TBI Participants and Investigators. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery. 2015 Jan;76(1):67-80. doi: 10.1227/NEU.0000000000000575.

  PMID: 25525693 DERIVED

Related Links

• CENTER - TBI website

Biospecimen

Retention: SAMPLES WITH DNA

whole blood samples

MeSH Terms

Conditions

Brain Injuries, Traumatic

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Results Point of Contact

• Title: Prof. Em. Dr Andrew Maas
• Organization: UZA

andrew.maas@uza.be

0032 3 821 45 37

Study Officials

• Andrew Maas, MD, PhD

  Antwerp University Hospital / University of Antwerp, Edegem, Belgium

  STUDY CHAIR

• David Menon, MD, PhD

  University of Cambridge, Addenbrookes hospital, Cambridge, UK

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: No
• Restriction Type: LTE60
• Restrictive Agreement: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D., PhD, Project Coordinator CENTER-TBI

Study Record Dates

• First Submitted: July 29, 2014
• First Posted: August 6, 2014
• Study Start: December 19, 2014
• Primary Completion: September 1, 2018
• Study Completion: March 31, 2021
• Last Updated: November 7, 2022
• Results First Posted: September 25, 2020

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will share

Locations

LI (3); HU (2); SE (1); GB (9); FI (2); IT (8); CH (1); FR (5); LA (3); NO (3); ES (4); BE (4); IL (2); NL (7); RO (1); DK (2); AU (2); DE (4)