Disability and HIV: Vulnerability of People With Disabilities to HIV Infection in Sub-Saharan Africa

NCT02192658 | Completed DMC

• 1 other identifier: ANRS 12302 - HandiVIH
• Study Type: observational
• Target: 1,610
• Locations: 1 country
• Sites: 1

Brief Summary

According to the recent World Report on Disability, around 15% of the world population lives with a disability and 80% of people with disabilities (PWD) live in developing countries. More and more evidence show that PWD are more likely to be poor, vulnerable to physical and sexual violence, and to have less access to education. Therefore, PWD are likely to have an increased risk for HIV infection, potentially being a key population in regard to this epidemic. The vulnerability of PWD was recognized in 2007 by the United Nations Convention on the Rights of Persons with Disabilities. However, data on the extent how PWD are affected by HIV is still very limited. As a result, PWD are usually overlooked by National AIDS Control Programmes and few projects specifically targeting them have been developed. Recognizing the need for appropriate and reliable data to help protect the rights of PWD and achieve a better inclusion of disability in National AIDS Control Programmes, the Institute of Research for Development (IRD), the Institut de Formation et Recherche Demographique (IFORD) and Handicap International (HI) propose this study that aims to provide quantitative and qualitative data on the vulnerability of PWD to HIV infection in Cameroon and Burkina Faso, in order to define if this vulnerable population is also a Key Population in relation to the HIV epidemic. This study adopts a multidisciplinary approach (quantitative and qualitative methods). Quantitative data are collected only in Cameroon. Only the quantitative study is described here.

Conditions

HIV; Reproductive Health; Disability

Outcome Measures

Primary Outcomes (1)

• HIV prevalence

  HIV prevalence among People With Disability compared to Non-Disabled People. HIV serology will be assessed by rapid diagnostic tests.

  10 months

Secondary Outcomes (1)

• Risk factors

  10 months

Other Outcomes (1)

• Access to care

  10 months

Study Arms (2)

People with Disability (PWD) (N= 850)

PWD will be identified thanks to the disability screening tool developped by the Washington Group (WG). This tool is based on the WHO International Classification of Functionning (ICF). A stratified cluster sampling in 2 steps will be used in both, Yaounde and Ouagadougou. Each city will be divided in enumeration areas (EAs). First step : EAs will be drawn randomly with probability proportional to their size in number of households. Second step: in each EA, 30 households will be randomly drawn and each person living in these households will be screened for disability with the WG tool, according to the inclusion and exclusion criteria.

Non-Disabled People (control group) (N= 850)

For each PWD, 1 non-disabled control person will be randomly chosen from the census list of the same enumeration area. Control will also be matched on age and sex.

Eligibility Criteria

• Age: 15 Years - 49 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Community sample: \- PWD are identified thanks to the disability screening tool developped by the Washington Group (WG). This tool is based on the WHO International Classification of Functionning (ICF). A stratified cluster sampling in 2 steps is used in Yaounde. The city has been divided in enumeration areas (EAs). First step : EAs are drawn randomly with probability proportional to their size in number of households. Second step: in each EA, 30 households are randomly drawn and each person living in these households is screened for disability with the WG tool, according to the inclusion and exclusion criteria. \- For each PWD, 1 non-disabled control person is randomly chosen from the census list of the same enumeration area. Controls are matched on age and sex.

You may qualify if:

• Age 15 to 49 years
• WG criteria: ≥ 1 major impairment or 2 minor difficulties with an activity
• Informed consent given

You may not qualify if:

• Any severe disease that, according to the investigator, precludes the participation of the subject to ANY aspect of the study
• Temporary impairment (\>1 year) which is likely to be cured quickly
• Subject consenting to none of the aspects of the study.
• For Non-Disabled People (control group):
• Age 15 to 45 years in an interval of 5 years compared to the index PWD;
• Same sex as the index PWD;
• Not answering to the WG criteria for disability;
• Living in the same enumeration area as the Index PWD;
• Informed consent given.
• Any conditions, that - according to the interviewer - don't permit to participate at any part of the study;
• Subject consenting to none of the aspects of the study.

Sponsors & Collaborators

• ANRS, Emerging Infectious Diseases: lead
• Handicap International: collaborator
• Institut de Recherche pour le Developpement: collaborator
• Institut de Formation et de Recherche Démographique: collaborator
• Forum Camerounais de Psychologie: collaborator
• Centre de Recherche Internationale pour la Santé de l'Université de Ouagadougou: collaborator

Study Sites (1)

Unknown Facility

Yaoundé, Cameroon

Location

Related Publications (1)

• De Beaudrap P, Pasquier E, Tchoumkeu A, Touko A, Essomba F, Brus A, Desgrees du Lou A, Aderemi TJ, Hanass-Hancock J, Eide AH, Mont D, Mac-Seing M, Beninguisse G. HandiVIH--A population-based survey to understand the vulnerability of people with disabilities to HIV and other sexual and reproductive health problems in Cameroon: protocol and methodological considerations. BMJ Open. 2016 Feb 4;6(2):e008934. doi: 10.1136/bmjopen-2015-008934.

  PMID: 26846895 DERIVED

Study Officials

• Pierre DE BEAUDRAP, MD, PhD

  Institut de Recherche pour le Developpement (IRD)

  STUDY DIRECTOR

• Gervais BENINGISSE, PhD

  Institut de Formation et Recherche Demographique (IFORD)

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 11, 2014
• First Posted: July 17, 2014
• Study Start: November 1, 2014
• Primary Completion: December 1, 2015
• Study Completion: July 1, 2016
• Last Updated: July 12, 2016

Record last verified: 2016-07

Locations

CA (1)