NCT02189460

Brief Summary

The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
33

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jul 2014

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2014

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

July 3, 2014

Completed
11 days until next milestone

First Posted

Study publicly available on registry

July 14, 2014

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2018

Completed
Last Updated

October 12, 2018

Status Verified

October 1, 2018

Enrollment Period

4 years

First QC Date

July 3, 2014

Last Update Submit

October 9, 2018

Conditions

Cognition

Keywords

Cognition

Outcome Measures

Primary Outcomes (2)

  • Blood Oxygen Level Dependent functional MRI

    We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects. We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.

    There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.

  • Anatomical MRI

    We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects. We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.

    There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year.

Study Arms (1)

Healthy adults

20 young adults aged between 30 and 50 years old. 20 middle aged adults aged between 50 and 70 years old. 20 older adults of 70 years old and more.

Eligibility Criteria

Age30 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

60 healthy adults will participate to the study. There will be 3 age groups: 30-50, 50-70, \> 70 years. Ech group will contain 20 volunteers. The volunteers are recruited by means of ads on Laboratory websites and Universities.

You may qualify if:

  • Age of 30 years and above
  • Right handed
  • French native speakers
  • Affiliation to French social security (Sécurité Sociale)
  • Medical interview
  • Consent form signed

You may not qualify if:

  • Cerebral or respiratory pathologies
  • Any MRI contrindication

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

IRMaGe facility

Grenoble, 38000, France

Location

Study Officials

  • Alexandre Krainik, Professor

    Neuroradiology department, Grenoble Hospital, INSERM, Grenoble University.

    PRINCIPAL INVESTIGATOR

  • Monica Baciu, Professor

    Laboratory of Psychology and NeuroCognition, CNRS, Grenoble University.

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 3, 2014

First Posted

July 14, 2014

Study Start

July 1, 2014

Primary Completion

July 1, 2018

Study Completion

July 1, 2018

Last Updated

October 12, 2018

Record last verified: 2018-10

Locations

FR(1)