NCT02189031

Brief Summary

Upper limb amputation is a devastating injury that leaves many thousands of typically young and active individuals in the US to rely on artificial arms and hands to help restore their lost function. The investigators research is focused on helping these individuals to feel where their prosthetic limbs are moving without having to look at them by developing devices and approaches to provide sensory feedback of limb movement through the nerves that once served the missing limb.

Trial Health

47
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
49

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Feb 2013

Longer than P75 for all trials

Geographic Reach
2 countries

4 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2013

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

July 8, 2014

Completed
6 days until next milestone

First Posted

Study publicly available on registry

July 14, 2014

Completed
10.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2024

Completed
Last Updated

November 21, 2023

Status Verified

March 1, 2023

Enrollment Period

11.6 years

First QC Date

July 8, 2014

Last Update Submit

November 17, 2023

Conditions

Keywords

Upper limb AmputeeTargeted Muscle ReinnervationProsthetic

Outcome Measures

Primary Outcomes (1)

  • Embodiment of the Prosthetic limb

    Visual loading for fine motor tasks,questionnaires, and residual limb temperature will be assessed after 10 months of in home every day use of a custom robust tactor array for sensory feedback.

    Ten months

Secondary Outcomes (1)

  • Investigate the perceptions of limb movement

    6 months

Study Arms (2)

Upper Extremity Amputee

Robust custom tactor to facilitate embodiment and proprioception

Device: Tactor array

Able Bodied

Bypass tactor

Device: Bypass Tactor

Interventions

Upper Extremity Amputee
Able Bodied

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Amputees who have undergone targeted sensory reinnervation

You may qualify if:

  • Amputee criteria:
  • Must be over 18 years of age
  • Must be upper extremity amputee who has undergone targeted sensory reinnervation.
  • Able Bodied participants:
  • Must be over 18 years of age

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Rehabilitation Institute of Chicago

Chicago, Illinois, 60611, United States

Location

Louis Stokes VA Medical Center

Cleveland, Ohio, 44106, United States

Location

Cleveland Clinic Lerner Research Institute

Cleveland, Ohio, 44195, United States

Location

University of Alberta Glenrose Rehabilitation Hospital

Edmonton, Alberta, T5B0B7, Canada

Location

Related Links

Study Officials

  • Paul Marasco, PhD

    Louis Stokes VA Medical Center, Cleveland Clinic Lerner Research Institute

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
FED
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director of Amputee Research

Study Record Dates

First Submitted

July 8, 2014

First Posted

July 14, 2014

Study Start

February 1, 2013

Primary Completion

September 1, 2024

Study Completion

September 1, 2024

Last Updated

November 21, 2023

Record last verified: 2023-03

Locations