NCT02178176

Brief Summary

The burden of diabetes is anticipated to grow yet the proportion of adults whose diabetes is controlled is decreasing over time. This project can have a significant public health impact because we are refining and pilot testing a primary-care based intervention aimed at improving patient engagement and function which are critical components of diabetes care and are associated with improved glycemic control, lower disease-related health-care expenditures, and reduced mortality.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
78

participants targeted

Target at P25-P50 for not_applicable depression

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2013

Completed
10 months until next milestone

First Submitted

Initial submission to the registry

June 26, 2014

Completed
4 days until next milestone

First Posted

Study publicly available on registry

June 30, 2014

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2015

Completed
Last Updated

May 17, 2016

Status Verified

May 1, 2016

Enrollment Period

1.4 years

First QC Date

June 26, 2014

Last Update Submit

May 13, 2016

Conditions

Outcome Measures

Primary Outcomes (3)

  • Depression: nine-item Patient Health Questionnaire (PHQ-9)

    Baseline and 14 weeks

  • Glycemic control: hemoglobin A1c

    Baseline and 14 weeks

  • Adherence to oral hypoglycemic agents: Medication Event Monitoring System

    Over 14 weeks

Study Arms (2)

Education, encouragement, card sort

EXPERIMENTAL
Behavioral: Education, encouragement, card sort

Education, encouragement

ACTIVE COMPARATOR
Behavioral: Education, encouragement

Interventions

Patients will identify factors involved in nonadherence. For each factor influencing adherence, the interventionist will engage the patient in a 4-step problem solving process. We will recognize patients' social and cultural context by addressing health-related priorities identified by the patient. The goal will be to identify those priorities which are likely to influence engagement in care and adherence to treatment. We will assess both biomedical (physical symptoms, diet and exercise) and nonbiomedical (financial, social and emotional) needs patients with Type 2 diabetes mellitus and depressive symptoms may wish to discuss in the context of their health. After the patients complete the card sort, interventionists will engage the patient in the 4-step problem solving process.

Education, encouragement, card sort

Patients will identify factors involved in nonadherence. For each factor influencing adherence, the interventionist will engage the patient in a 4-step problem solving process.

Education, encouragement

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years and older
  • a current diagnosis of Type 2 DM
  • HbA1c 7%
  • current prescription for an oral hypoglycemic agent
  • able to communicate in English
  • willing to give informed consent

You may not qualify if:

  • acutely suicidal or psychotic (patients will not be randomized and PI or physician covering for PI will be paged immediately)
  • significant cognitive impairment at baseline (a total score on Mini-Mental State Examination (MMSE) 21)
  • markedly shortened life expectancy (diagnosis of metastatic cancer, end-stage renal disease on dialysis, or NYHA Class III or IV congestive heart failure)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

MeSH Terms

Conditions

DepressionDiabetes Mellitus, Type 2

Interventions

Educational Status

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehaviorDiabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Intervention Hierarchy (Ancestors)

Socioeconomic FactorsPopulation Characteristics

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

June 26, 2014

First Posted

June 30, 2014

Study Start

September 1, 2013

Primary Completion

February 1, 2015

Last Updated

May 17, 2016

Record last verified: 2016-05

Locations