NCT02166372

Brief Summary

T2DM has become a major health burden for our society. More and more data support the relative effectiveness of gastrointestinal metabolic surgery, known as bariatric surgery, in the remission of T2DM of BMI less35. The metabolic surgery guidelines of IDF recommend BMI over 27.5 in Asia. The evidence reviewed above strongly points to the need for a large randomized, controlled trial to evaluate the risks and benefits of obesity surgery in the treatment of type 2 diabetes Mellitus. This study is expected to provide very significant findings about the natural course of diabetes in obese diabetic patients.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
105mo left

Started Mar 2014

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress59%
Mar 2014Dec 2034

Study Start

First participant enrolled

March 1, 2014

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

June 16, 2014

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 18, 2014

Completed
10.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2024

Completed
10 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2034

Expected
Last Updated

June 18, 2014

Status Verified

June 1, 2014

Enrollment Period

10.8 years

First QC Date

June 16, 2014

Last Update Submit

June 16, 2014

Conditions

Outcome Measures

Primary Outcomes (1)

  • Evaluate the natural course of the diabetes of obese patients over a period of 10 years

    ten years

Study Arms (1)

Obese diabetic patients

Diabetic patients with BMI over 25 Age 20 to 67 Diabetes medically controlled at our center for at least six months

Other: Observation of natural course of Diabetes Mellitus Type 2

Interventions

Eligibility Criteria

Age20 Years - 67 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Diabetic patients in Taiwan

You may qualify if:

  • Diabetic Mellitus Type 2 medically controlled at Diabetes Center for at least six months
  • BMI over 25
  • age between 20 and 67

You may not qualify if:

  • Diagnosed with cancer within past five years
  • HIV positive
  • Active TB patients
  • CV events in past six months
  • serum cretinine over 2.0 mg/dl
  • C-peptide bellow 1.0 ng/ml in past three months
  • Diabetic retinopathy; vision bellow 0.1
  • Cushing's syndrome
  • History of organ transplant
  • History of bariatric surgery
  • History of alcohol or drug dependency in past five years
  • Psychological problems likely to interfere with adherence to protocol

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Min-Sheng General Hospital

Taoyuan, 33044, Taiwan

RECRUITING

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Wei-Jei Lee, MD PhD

    Min-Sheng General Hospital; National Taiwan University Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

June 16, 2014

First Posted

June 18, 2014

Study Start

March 1, 2014

Primary Completion

December 1, 2024

Study Completion (Estimated)

December 1, 2034

Last Updated

June 18, 2014

Record last verified: 2014-06

Locations