Iron Homoeostasis in Inflammation
1 other identifier
observational
472
1 country
1
Brief Summary
The purpose of this study is to survey iron storage levels and their prognostic consequences in the context of acute inflammation. The impact of iron substitution in inflammatory states is controversial. We hypothesize that iron substitution may influence outcome in patients in inflammatory states.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2014
CompletedFirst Submitted
Initial submission to the registry
June 2, 2014
CompletedFirst Posted
Study publicly available on registry
June 4, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2014
CompletedNovember 13, 2014
November 1, 2014
6 months
June 2, 2014
November 11, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Prevalence of different iron states (normal iron states, iron deficiency and iron overload) in the context of acute inflammation
up to 8 days
Secondary Outcomes (1)
Correlation between iron states and clinical course of acute inflammation, mode of discharge and iron substitution
up to 8 days
Eligibility Criteria
Consecutive internal medicine inpatients with laboratory signs of inflammation
You may qualify if:
- Age: ≥18
- Hospitalized patient in internal medicine (≥ 24h)
- Evidence of an inflammatory state, determined as a C reactive protein (CRP) value \>5 mg/l
- Written informed consent
You may not qualify if:
- History of terminal renal insufficiency in terms of dialysis or use of erythropoiesis-stimulating agents
- Pregnancy
- History of allogeneic stem cell transplantation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Basel University Hospital
Basel, 4031, Switzerland
Related Publications (5)
Hug BL, Tichelli A, Benkert P, Stirnimann G, Schifferli JA. Diagnosis and treatment of iron deficiency in medical inpatients at a Swiss tertiary university referral hospital: a retrospective observational cohort study of clinical practice. Swiss Med Wkly. 2013 Sep 6;143:w13847. doi: 10.4414/smw.2013.13847. eCollection 2013.
PMID: 24018778BACKGROUNDThomas DW, Hinchliffe RF, Briggs C, Macdougall IC, Littlewood T, Cavill I; British Committee for Standards in Haematology. Guideline for the laboratory diagnosis of functional iron deficiency. Br J Haematol. 2013 Jun;161(5):639-648. doi: 10.1111/bjh.12311. Epub 2013 Apr 10. No abstract available.
PMID: 23573815BACKGROUNDFinberg KE. Unraveling mechanisms regulating systemic iron homeostasis. Hematology Am Soc Hematol Educ Program. 2011;2011:532-7. doi: 10.1182/asheducation-2011.1.532.
PMID: 22160085BACKGROUNDDrakesmith H, Prentice AM. Hepcidin and the iron-infection axis. Science. 2012 Nov 9;338(6108):768-72. doi: 10.1126/science.1224577.
PMID: 23139325BACKGROUNDOppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr. 2001 Feb;131(2S-2):616S-633S; discussion 633S-635S. doi: 10.1093/jn/131.2.616S.
PMID: 11160594BACKGROUND
Biospecimen
blood samples (serum and heparinized plasma)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Balthasar L. Hug, MD, MBA, MPH
Division of Internal Medicine, University Hospital Basel, Switzerland
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 2, 2014
First Posted
June 4, 2014
Study Start
April 1, 2014
Primary Completion
October 1, 2014
Last Updated
November 13, 2014
Record last verified: 2014-11