Trials Sponsors Conditions Drugs Pricing

Conditions

Constrictive Bronchitis COPD Healthy

Keywords

Hyperpolarized gas MRI

Outcome Measures

Primary Outcomes (1)

Hyperpolarized helium MRI flow velocity map
Using hyperpolarized helium as an inhaled contrast agent for MRI, we will measure the velocity of inhaled breath in the trachea.
Day 1

Secondary Outcomes (2)

Hyperpolarized helium MRI flow velocity map
Day1
Hyperpolarized helium-3 MRI flow velocity map
Day 1

Study Arms (1)

Hyperpolarized helium MRI of the chest

EXPERIMENTAL

The purpose of this study is to look at the airflow in the lungs of healthy subjects and subjects with lung disease using Magnetic Resonance Imaging (MRI) with inhaled hyperpolarized helium-3 gas.

Drug: hyperpolarized helium-3 gas with MRI of the chest

Interventions

hyperpolarized helium-3 gas with MRI of the chestDrug

Using hyperpolarized helium as an inhaled gaseous contrast agent for MRI, we will measure the velocity of inhaled breath in the trachea.

Also known as: 3He hyperpolarized MRI

Hyperpolarized helium MRI of the chest

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Healthy subjects:
Normal PFT values: FEV1 \> 90% predicted; and Forced vital capacity (FVC) \> 90% predicted

Sponsors & Collaborators

University of Virginia
Otherlead

Study Sites (2)

Snyder Translation Fontaine Research Center 480 Ray C. Hunt Drive

Charlottesville, Virginia, 22908, United States

University of Virginia Health System

Charlottesville, Virginia, 22908, United States

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

Yun M Shim, MD
University of Virginia Department of Pulmonary and Critical Care Medicine
PRINCIPAL INVESTIGATOR

Enrollment

24 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: BASIC SCIENCE
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Associate Professor

Study Record Dates

First Submitted

May 30, 2014

First Posted

June 3, 2014

Study Start

November 7, 2013

Actual (reported)

Study of Airflow in the Lungs Using Helium MRI

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (1)

Hyperpolarized helium MRI of the chest

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (2)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (1)

Hyperpolarized helium MRI of the chest

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (2)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations