Influence of Trigger Threshold on Controlled Twitch Mouth Pressure
1 other identifier
interventional
30
1 country
1
Brief Summary
The inspiratory pressure trigger is essential when assessing the twitch mouth pressure (Tw Pmo) for avoiding glottic closure. However, the difference in inspiratory pressure trigger threshold may influence the values of Tw Pmo. We sought to determine the trigger threshold for healthy subjects and COPD patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jun 2012
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2013
CompletedFirst Submitted
Initial submission to the registry
June 26, 2013
CompletedFirst Posted
Study publicly available on registry
July 3, 2013
CompletedJuly 3, 2013
June 1, 2013
1 year
June 26, 2013
July 2, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Twitch mouth pressure
2 weeks
Secondary Outcomes (1)
Twitch oesophageal pressure
2 weeks
Study Arms (2)
COPD patients
EXPERIMENTALAll of the COPD patients included in this study were stable with no episodes of exacerbation within the previous 2 months. Patients with COPD were not currently being treated with oral corticosteroids.
normal subjects
EXPERIMENTALFifteen healthy men with normal lung function
Interventions
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of COPD
- Stable with no episodes of exacerbation within the previous 2 months
- Do not currently being treated with oral corticosteroids
You may not qualify if:
- Not stable within the previous 2 months.
- Patients with COPD were currently being treated with oral corticosteroids
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Guangzhou Institute Respiratory Disease
Guangzhou, Guangdong, 510120, China
Related Publications (2)
Walker DJ, Ertl T, Walterspacher S, Schlager D, Roecker K, Windisch W, Kabitz HJ. Respiratory muscle function during a six-week period of normocapnic hyperpnoea training. Respir Physiol Neurobiol. 2013 Aug 15;188(2):208-13. doi: 10.1016/j.resp.2013.05.005. Epub 2013 May 17.
PMID: 23689008RESULTHua DM, Liang YH, Xie YK, Liu Q, Zheng ZG, Chen RC, Zhong NS. Use of twitch mouth pressure to assess diaphragm strength in patients with chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 2013 Jul 1;187(3):211-6. doi: 10.1016/j.resp.2013.04.012. Epub 2013 Apr 15.
PMID: 23597835RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Rong-chang Chen, Master
Guangzhou Instiute of Respiratory Disease
- PRINCIPAL INVESTIGATOR
Dong-ming Hua, Master
Guangzhou Institue of Respiratory Disease
- STUDY CHAIR
Nan-shan Zhong, Bachelor
Guangzhou Institue of Respiratory Disease
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- DIAGNOSTIC
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Influence of Trigger Threshold on Controlled Twitch Mouth Pressure
Study Record Dates
First Submitted
June 26, 2013
First Posted
July 3, 2013
Study Start
June 1, 2012
Primary Completion
June 1, 2013
Study Completion
June 1, 2013
Last Updated
July 3, 2013
Record last verified: 2013-06