Training Effects on Fuel Metabolism

NCT02150889 | Active Not Recruiting

• 2 other identifiers: 1209M207415R01DK098203-02
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. The investigators are especially interested in learning about the effects of weight and training on insulin resistance. The investigators will study people before and after supervised aerobic or yoga training to identify differences in resting fat and sugar metabolism which may lead to differences in insulin resistance. The investigators will test these differences using stable isotopes, and the use of these stable isotopes is experimental. Overweight/Obese Group: Eight visits will be required at the University of Minnesota Clinical Research Unit. Four visits will be done before training (screen and 3 pre-training visits), 1 visit during the training, and 3 post-training visits will be done. In between, the training will take about 16 weeks and will be a supervised treadmill program. Lean/Trained Group: Four visits will be required at the University of Minnesota Clinical Research Unit (screen and 3 study visits).

Conditions

Overweight and Obesity; Healthy Subjects; Lean Trained Subjects

Keywords

insulin resistance; lipid metabolism; diabetes

Outcome Measures

Primary Outcomes (1)

• Differences in insulin sensitivity between groups

  Will use HOMA-IR and hyperinsulinemia-euglycemic clamp

  Before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks)

Secondary Outcomes (1)

• Differences in fitness level between groups

  before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks)

Other Outcomes (1)

• Differences in body composition between groups

  before and after exercise program ((exercise program will take 16 weeks, expected average for evaluation will be 20 weeks)

Study Arms (2)

Lean Trained

NO INTERVENTION

Metabolic control

Obese or Overweight

EXPERIMENTAL

Running Program Yoga Program

Behavioral: Running Program; Behavioral: Yoga Program

Interventions

Running Program BEHAVIORAL

16 week supervised running program

Obese or Overweight

Yoga Program BEHAVIORAL

once weekly supervised yoga

Obese or Overweight

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• All subjects
• Subjects 18 to 40 years of age.
• Subjects are capable of giving informed consent
• Overweight or obese
• Insulin resistant based on screening oral glucose tolerance testing.
• BMI 25 to 40 kg/m2 inclusive
• Stable weight for at least 3 months (± 5 lbs.)
• Sedentary status (self-report \< 30 minutes/week regular exercise).
• Lean, physically active
• physically active subjects defined as 3-5 aerobic exercise sessions/week
• matched to age and gender
• generally healthy with normal fasting glucose levels (glucose ≤100 mg/dL).

You may not qualify if:

• All subjects
• Subjects 18 to 40 years of age.
• Subjects are capable of giving informed consent
• Overweight or obese
• Insulin resistant based on screening oral glucose tolerance testing.
• BMI 25 to 40 kg/m2 inclusive
• Stable weight for at least 3 months (± 5 lbs.)
• Sedentary status (self-report \< 30 minutes/week regular exercise).
• Lean, physically active
• physically active subjects defined as 3-5 aerobic exercise sessions/week
• matched to age and gender
• generally healthy with normal fasting glucose levels (glucose ≤100 mg/dL).

Sponsors & Collaborators

• University of Minnesota: lead
• National Institutes of Health (NIH): collaborator
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): collaborator

Study Sites (1)

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

Related Publications (2)

• Nelson AB, Chow LS, Stagg DB, Gillingham JR, Evans MD, Pan M, Hughey CC, Myers CL, Han X, Crawford PA, Puchalska P. Acute aerobic exercise reveals that FAHFAs distinguish the metabolomes of overweight and normal-weight runners. JCI Insight. 2022 Apr 8;7(7):e158037. doi: 10.1172/jci.insight.158037.

  PMID: 35192550 DERIVED

• Bantle AE, Bosch TA, Dengel DR, Wang Q, Mashek DG, Chow LS. DXA-Determined Regional Adiposity Relates to Insulin Resistance in a Young Adult Population with Overweight andObesity. J Clin Densitom. 2019 Apr-Jun;22(2):287-292. doi: 10.1016/j.jocd.2018.06.001. Epub 2018 Jun 7.

  PMID: 30064815 DERIVED

MeSH Terms

Conditions

Overweight; Obesity; Insulin Resistance; Diabetes Mellitus

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases

Study Officials

• Lisa S. Chow, MD

  University of Minnesota

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 22, 2014
• First Posted: May 30, 2014
• Study Start: July 1, 2014
• Primary Completion: December 30, 2018
• Study Completion (Estimated): December 31, 2026
• Last Updated: January 8, 2026

Record last verified: 2026-01

Locations

US (1)