Steviol Glycoside for Use in Restoring Muscle Glycogen by Increasing the Rate of Glycogen Re-synthesis in Muscles

NCT02146183 | Unknown

• 1 other identifier: Aarhus University
• Study Type: interventional
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this experiment is to investigate if intake of stevioside in addition to a carbohydrate-containing composition after work related depletion of muscle glycogen will increase the rate of glycogen re-synthesis as compared with intake of the carbohydrate-containing composition alone.

Conditions

Glycogen Depletion

Keywords

Stevio glycosides; sport; glycogen

Outcome Measures

Primary Outcomes (1)

• Effects on glycogen re-synthesis

  During the working session the test subjects will be exercising for 2 hours on a bicycle ergometer at 65-75% of VO2-max. Immediately after the working session the test subject will be given a carbohydrate-containing composition that comprises 2 g carbohydrate per kg of body weight. Also 2 hours after completion of the working session the test persons will be given a carbohydrate-containing composition that comprises 2 g carbohydrate per kg of body weight. These compositions will be added either 500 mg stevioside or placebo (starch corn). After collection of the muscle biopsies the samples will be stored under liquid nitrogen. The parameter evaluated in the muscles biopsies will be glycogen.

  2 weeks

Study Arms (2)

placebo / Corn starch

PLACEBO COMPARATOR

Carbohydrate-containing composition that comprises 2 g carbohydrate per kg of body weight. This composition will be 500 mg placebo starch corn.

Dietary Supplement: Placebo Corn Starch

Carbohydrate steviol glycosides

ACTIVE COMPARATOR

500 mg steviol glycosides.

Dietary Supplement: Carbohydrate steviol glycosides

Interventions

Carbohydrate steviol glycosides DIETARY_SUPPLEMENT

To investigate if intake of stevioside in addition to a carbohydrate-containing composition after work related depletion of muscle glycogen will increase the rate of glycogen re-synthesis as compared with intake of the carbohydrate-containing composition alone.

Carbohydrate steviol glycosides

Placebo Corn Starch DIETARY_SUPPLEMENT

500 mg/day

placebo / Corn starch

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy and well trained, sporty exhaustive trained males, age 18 to 40 years old.

You may not qualify if:

• Persons suffering of a metabolic disease, which is related to the carbohydrate metabolism, such as diabetes type 1 or 2, insulin resistance and the like, cannot be included in the test. Also persons, who are prescribed a medical drug or diet supplement that could affect the carbohydrate metabolism, will be excluded from the study. Finally persons that are not capable of completing the fasting period or the test design will be excluded from the study.

Sponsors & Collaborators

• Per Bendix Jeppesen: lead
• University of Aarhus: collaborator
• Aarhus University Hospital: collaborator

Study Sites (1)

Aarhus University Hospital, Dept of Clinical medicine

Aarhus C, 8000, Denmark

RECRUITING

Study Officials

• Per B Jeppesen, Prof., PhD

  Aarhus University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Per B Jeppesen, prof, PhD

CONTACT

-4528151877; per.bendix.jeppesen@ki.au.dk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Prof, PhD

Study Record Dates

• First Submitted: May 21, 2014
• First Posted: May 23, 2014
• Study Start: September 1, 2013
• Primary Completion: February 1, 2015
• Study Completion: July 1, 2015
• Last Updated: May 23, 2014

Record last verified: 2014-05

Locations

DK (1)