Effects of Transcranial Direct Current Stimulation on Cigarette Addiction

NCT02146014 | Completed

• 1 other identifier: TAB-69168
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Tobacco addiction is treatable with behavioral and pharmacological means, but results are often less than optimal. Transcranial direct current stimulation is a new non-invasive technique that applies weak electrical currents through the skull and has been shown to alter the excitability of certain brain areas. It is currently being tried in disorders where there is abnormal brain excitability, such as epilepsy and depression. A few studies have also been able to diminish drug craving, suggesting that brain excitability might also be altered in drug addiction. This study aims at non-invasively changing the excitability of certain brain areas-a procedure called neuromodulation- in order to help smokers quit smoking more easily.

Conditions

Addiction

Keywords

cigarette smoking, smoking

Outcome Measures

Primary Outcomes (1)

• Change in Visual Analogue Scale of Cigarette Craving

  Before and 7 days after treatment

Secondary Outcomes (1)

• Change in Visual Analogue Scale of Motivation to Quit Smoking

  Before and 7 days after intervention

Study Arms (2)

Transcranial Direct Current Stimulation

EXPERIMENTAL

These subjects will receive real transcranial direct current stimulation.

Device: Transcranial Direct Current Stimulation

Sham tDCS

PLACEBO COMPARATOR

These subjects will receive sham transcranial direct current stimulation (placebo)

Other: Placebo

Interventions

Placebo OTHER

Transcranial Direct Current Stimulation (tDCS) is a procedure that uses a small battery-driven unit to deliver weak electrical currents (1-2 mA) through the intact scalp. The procedure is painless and is thought to modulate the excitability of the underlying cerebral tissue for hours or days after sessions. In the placebo group the current will be off.

Sham tDCS

Transcranial Direct Current Stimulation DEVICE

Transcranial Direct Current Stimulation (tDCS) is a procedure that uses a small battery-driven unit to deliver weak electrical currents (1-2 mA) through the intact scalp. The procedure is painless and is thought to modulate the excitability of the underlying cerebral tissue for hours or days after sessions.

Transcranial Direct Current Stimulation

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• smokers

You may not qualify if:

• use of psychoactive drugs
• age above 70

Sponsors & Collaborators

• University of Brasilia: lead

Study Sites (1)

Hospital Universitário de Brasília- HUB

Brasília, Federal District, 71910-900, Brazil

Location

Related Publications (1)

• Vitor de Souza Brangioni MC, Pereira DA, Thibaut A, Fregni F, Brasil-Neto JP, Boechat-Barros R. Effects of Prefrontal Transcranial Direct Current Stimulation and Motivation to Quit in Tobacco Smokers: A Randomized, Sham Controlled, Double-Blind Trial. Front Pharmacol. 2018 Jan 26;9:14. doi: 10.3389/fphar.2018.00014. eCollection 2018.

  PMID: 29434547 DERIVED

MeSH Terms

Conditions

Behavior, Addictive; Cigarette Smoking

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Compulsive Behavior; Impulsive Behavior; Behavior; Tobacco Smoking; Smoking; Tobacco Use

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Officials

• Raphael Boechat-Barros, MD

  University of Brasilia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: May 13, 2014
• First Posted: May 23, 2014
• Study Start: May 1, 2010
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: June 1, 2016

Record last verified: 2016-05

Locations

BR (1)