Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection
Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection: the Effect of Pretreatment With Antiglaucoma Agents
1 other identifier
interventional
70
1 country
1
Brief Summary
To assess the effect of prophylactic antiglaucoma agents in prevention of acute intraocular pressure rise after intravitreal injection.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Feb 2012
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2014
CompletedFirst Submitted
Initial submission to the registry
May 9, 2014
CompletedFirst Posted
Study publicly available on registry
May 16, 2014
CompletedMay 16, 2014
May 1, 2014
1.9 years
May 9, 2014
May 13, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
change in IOP
the change in intraocular pressure after intravitreal injection of bevacizumab
0, 5, 10, 15, 30 minutes after injection
Study Arms (5)
Timolol
ACTIVE COMPARATORTimolol eyedrop, 2 drops 5 minutes apart, 1-2 hours before intravitreal injection
Brimonidine
ACTIVE COMPARATORBrimonidine eyedrop, 2 drops 5 minutes apart, 1-2 hours before intravitreal injection
Acetazolamide
ACTIVE COMPARATORAcetazolamide tablet, 2 tabs, 2 hours before intravitreal injection
Mannitol
ACTIVE COMPARATORIntravenous mannitol, 1.5 gram/kg, 1 hour before intravitreal injection
Placebo
SHAM COMPARATORArtificial tears, 2 drops, 1-2 hours before intravitreal injection
Interventions
2 drops of timolol, 10 minutes apart, 1-2 hours before intravitreal injection
Brimonidine eyedrop, 2 drops 5 minutes apart, 1-2 hours before intravitreal injection
Acetazolamide tablet, 2 tabs, 2 hours before intravitreal injection
Artificial tears, 2 drops, 1-2 hours before intravitreal injection
Eligibility Criteria
You may qualify if:
- all patients who candidate for receiving intravitreal bevacizumab
You may not qualify if:
- patients who had advanced glaucoma
- patients who received antiglaucoma agents in the past
- patients who had corneal scar which affect IOP measurement
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Retina Research Center, Khatam eye Hospital
Mashhad, Khorasan Razavi, Iran
Related Publications (1)
Shoeibi N, Ghosi Z, Jafari H, Omidtabrizi A. Effect of antiglaucoma agents on short-term intraocular pressure fluctuations after intravitreal bevacizumab injections. Int Ophthalmol. 2021 Mar;41(3):1081-1090. doi: 10.1007/s10792-020-01667-z. Epub 2021 Jan 2.
PMID: 33389369DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nasser Shoeibi, M.D.
Retina Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of Ophthalmology
Study Record Dates
First Submitted
May 9, 2014
First Posted
May 16, 2014
Study Start
February 1, 2012
Primary Completion
January 1, 2014
Study Completion
May 1, 2014
Last Updated
May 16, 2014
Record last verified: 2014-05