Representation of the Bladder Innervation Using Diffusion Tensor Imaging Fiber Tracking With MRI - a Pilot Study

NCT02138201 | Completed

• 1 other identifier: 2013-25
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The exact innervation of the bladder and the changes after a spinal cord injury have been not yet been illustrated. Diffusion tensor imaging with magnetic resonance imaging is a new technique which can be used to visualize single nerve fibers, and thus represent the neural supply of a region in vivo. There are studies in which both the sacral plexus and the lumbar nerve roots have been represented using diffusion tensor imaging. However, there is no study concerning the innervation of the bladder. The investigators are therefore using diffusion tensor imaging with magnetic resonance imaging to represent the bladder innervation of individuals with neurogenic lower urinary tract dysfunction and individuals with normal bladder function.

Conditions

Spinal Cord Injury; Neurogenic Lower Urinary Tract Dysfunction

Keywords

diffusion tensor imaging fiber tracking; magnetic resonance Imaging; spinal cord injury; neurogenic lower urinary tract dysfunction

Outcome Measures

Primary Outcomes (1)

• bladder innervation quality

  bladder innervation is illustrated using diffusion tensor imaging fiber tracking with magnetic resonance imaging

  day 0

Study Arms (2)

control

individuals with normal bladder function

neurogenic bladder

individuals suffering from neurogenic lower urinary tract dysfunction

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

individuals with and without neurogenic lower urinary trat dysfunction

You may qualify if:

• neurogenic lower urinary trat dysfunction
• normal bladder function

You may not qualify if:

• no signed informed consent
• contraindications for MRI (pace maker, implanted metal, claustrophobia)
• upper or lower urinary tract surgeries
• pregnancy (anamnestic)

Sponsors & Collaborators

• Swiss Paraplegic Research, Nottwil: lead

Study Sites (1)

Swiss Paraplegic Centre

Nottwil, Canton of Lucerne, CH-6207, Switzerland

Location

MeSH Terms

Conditions

Spinal Cord Injuries

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Wounds and Injuries

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 5, 2014
• First Posted: May 14, 2014
• Study Start: January 1, 2014
• Primary Completion: November 1, 2015
• Study Completion: November 1, 2015
• Last Updated: November 17, 2015

Record last verified: 2015-11

Locations

CH (1)