Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery
Effect of Propofol and Sevoflurane on Serum CD39 and CD73 Level After Open Heart Surgery With Cardiopulmonary Bypass
1 other identifier
interventional
2
1 country
1
Brief Summary
CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression. Propofol and volatile anesthetics were related to immune reaction. However, the effect of propofol and sevoflurane on the change of CD39 and CD73 after CPB was not evaluated in previous studies. The authors hypothesized that the expression of CD39 and CD73 would differ between propofol- and volatile anaesthetic-based anaesthesia in patients undergoing CPB. Therefore, the present study determined the effect of propofol and sevoflurane on CD39 and CD73 during and after CPB.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_4
Started May 2014
Typical duration for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 7, 2014
CompletedFirst Posted
Study publicly available on registry
May 13, 2014
CompletedStudy Start
First participant enrolled
May 21, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
August 10, 2017
CompletedJanuary 18, 2018
January 1, 2018
2.6 years
May 7, 2014
January 16, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
The level of CD39 and CD73 between propofol and sevoflurane group after CPB
The difference of CD39 and CD73 level between propofol and sevoflurane group
from preoperative status up to 48 hrs after CPB weaning status
Study Arms (2)
Propofol group
ACTIVE COMPARATORpatients with propofol-based anesthesia
Sevoflurane group
ACTIVE COMPARATORpatients with sevoflurane-based anesthesia
Interventions
group of patients with propofol-based anesthesia
group of patients with sevoflurane-based anesthesia
Eligibility Criteria
You may qualify if:
- patients scheduled to undergo elective cardiac surgery
- signed written informed consent agreements
You may not qualify if:
- Emergency operation that could not obtain pre-CPB1 sample
- Patients who have infectious factor before operation
- Patients who have immunosuppressive agent for underlying disease before operation
- Patients who have history of cancer previously
- Patients who are younger than 19 years old
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Konkuk University Medical Center
Seoul, 143-729, South Korea
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Seong-Hyop Kim, M.D, Ph.D
Konkuk University Medical Center
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
May 7, 2014
First Posted
May 13, 2014
Study Start
May 21, 2014
Primary Completion
December 31, 2016
Study Completion
August 10, 2017
Last Updated
January 18, 2018
Record last verified: 2018-01