Body and Brain Exercise for Older Adults With Memory Complaints

NCT02136368 | Completed

• 1 other identifier: M4W18858
• Study Type: interventional
• Target: 127
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate whether an exercise class with a cognitive (or brain) training component was more effective than a usual combined aerobic and resistance exercise class for older adults with cognitive complaints (such as concerns about changes in memory or thinking skills). It is hypothesized that the group randomized to the exercise class that includes additional brain training will have greater improvements in brain health.

Conditions

Cognitive Ability, General

Keywords

older adults; multiple-modality exercise; mind-motor exercise; self-reported cognitive complaints; global cognitive functioning; mobility; vascular function; sensorimotor function; brain imaging; community-based research; subjective cognitive complaints

Outcome Measures

Primary Outcomes (1)

• Composite score from Cambridge Brain Sciences Cognitive Battery - 12 tasks

  To assess global cognitive function

  6 months

Secondary Outcomes (17)

• Composite score from Cambridge Brain Sciences Cognitive Battery - 12 tasks

  12 months

• Gait variability (stride time) under dual-task conditions

  6 & 12 months

• Gait variability (stride time) under single-task conditions

  6 & 12 months

• Gait velocity (speed) under dual-task conditions

  6 & 12 months

• Gait velocity (speed) under single-task conditions

  6 & 12 months

Other Outcomes (4)

• Prosaccade reaction time in response to flash of light.

  6 months

• Change in blood flow to the pre-frontal cortex in response to a randomly selected cognitive task.

  6 months

• Antisaccade reaction time in response to flash of light.

  6 months

Study Arms (2)

Multi-Modal, Mind Motor Exercise (M4)

EXPERIMENTAL

Attend 60 minute exercise class three times per week for 24 weeks. Exercise class includes 45 minutes of multi-modal exercise and 15 minutes of mind-motor exercise.

Behavioral: Multi-modal exercise; Behavioral: Mind-Motor Exercise

Multi-Modal Exercise (M2)

ACTIVE COMPARATOR

Attend 60 minute exercise class three times per week for 24 weeks. Exercise class includes 45 minutes of multi-modal exercise and 15 minutes of balance and range of motion exercises.

Behavioral: Multi-modal exercise; Behavioral: Balance and range of motion exercises

Interventions

Multi-modal exercise BEHAVIORAL

Community-based group exercise classes following Canadian Centre for Activity and Aging exercise guidelines. Exercise classes consist of 5 min warm-up, 20 min aerobic exercise, 5 min aerobic cool-down, 10 min full-body resistance exercise, 5 min stretching (total 45 min)

Also known as: Exercise intervention

Multi-Modal Exercise (M2); Multi-Modal, Mind Motor Exercise (M4)

Mind-Motor Exercise BEHAVIORAL

Square Step Exercise involves mimicking a stepping pattern demonstrated by an instructor. The stepping patterns become progressively difficult and involve forward, backward, lateral and diagonal movements on a 250cm long mat with 25cm square grids (15 min).

Also known as: Square Stepping Exercise

Multi-Modal, Mind Motor Exercise (M4)

Balance and range of motion exercises BEHAVIORAL

Community-based group exercise designed to improve balance and range of motion of the joints (15 min)

Multi-Modal Exercise (M2)

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• aged 55 years or older
• self-reported cognitive complaint (defined as answering yes to the question "Do you feel like your memory or thinking skills have gotten worse recently?).
• independent on instrumental activities of daily living

You may not qualify if:

• Probable Dementia (i.e., diagnosis OR Mini-Mental State Examination score \<24)
• Other neurological conditions or major psychiatric disorders (i.e., Parkinson's disease; bipolar disorder)
• Previous history of severe cardiovascular conditions (i.e., myocardial infarction or stroke \<1-year ago; end stage congestive heart failure; end stage renal disease)
• Severe sensory impairment (i.e., blind)
• Significant orthopedic conditions (i.e., severe osteoarthritis)
• Clinical depression (determined via \>=16 on the Center for Epidemiologic Studies - Depression Scale AND review by primary study physician)
• Have blood pressure \>180/100 mmHg or \<100/60 mmHg
• Unable to comprehend questionnaire material
• Any other factors that could potentially limit ability to fully participate in the intervention

Sponsors & Collaborators

• London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's: lead
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (1)

Gymnasium

Woodstock, Ontario, N4V 0B1, Canada

Location

Related Publications (2)

• Boa Sorte Silva NC, Nagamatsu LS, Gill DP, Owen AM, Petrella RJ. Memory Function and Brain Functional Connectivity Adaptations Following Multiple-Modality Exercise and Mind-Motor Training in Older Adults at Risk of Dementia: An Exploratory Sub-Study. Front Aging Neurosci. 2020 Feb 25;12:22. doi: 10.3389/fnagi.2020.00022. eCollection 2020.

  PMID: 32158386 DERIVED

• Gregory MA, Gill DP, Shellington EM, Liu-Ambrose T, Shigematsu R, Zou G, Shoemaker K, Owen AM, Hachinski V, Stuckey M, Petrella RJ. Group-based exercise and cognitive-physical training in older adults with self-reported cognitive complaints: The Multiple-Modality, Mind-Motor (M4) study protocol. BMC Geriatr. 2016 Jan 16;16:17. doi: 10.1186/s12877-016-0190-9.

  PMID: 26772171 DERIVED

MeSH Terms

Interventions

Range of Motion, Articular

Intervention Hierarchy (Ancestors)

Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Robert J Petrella, MD, PhD

  The University of Western Ontario

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 29, 2014
• First Posted: May 13, 2014
• Study Start: January 1, 2014
• Primary Completion: September 1, 2015
• Study Completion: March 1, 2016
• Last Updated: September 7, 2016

Record last verified: 2016-09

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)