Reasoning Training in Individuals With Bipolar Disorder

NCT02843282 | Completed Results

• 1 other identifier: 14-16
• Study Type: interventional
• Target: 27
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to examine cognitive and brain changes in individuals with bipolar disorder as a result of a cognitive training intervention.

Conditions

Bipolar Disorder; Cognitive Ability, General

Outcome Measures

Primary Outcomes (1)

• Change From Baseline: Test of Strategic Learning

  Complex abstraction subtest: After reading a complex text, participants generate a high-level synthesis of abstracted ideas (versus recall of concrete details). \[raw scores, min value = 0, max value = 10, higher indicates better performance\]

  Pre and within 2 weeks post intervention

Secondary Outcomes (12)

• Change From Baseline: Wechsler Adult Intelligence Scale (WAIS), Similarities Subtest

  Pre and within 2 weeks post intervention

• Change From Baseline: Delis-Kaplan Executive Function System (DKEFS) Card Sorting

  Pre and within 2 weeks post intervention

• Change From Baseline: Working Memory (Digits Backwards)

  Pre and within 2 weeks post intervention

• Change From Baseline: Delis-Kaplan Executive Function System (DKEFS) Color-Word, Inhibition & Switching Subtest

  Pre and within 2 weeks post intervention

• Change From Baseline: Divided Attention

  Pre and within 2 weeks post intervention

Study Arms (1)

Cognitive training

EXPERIMENTAL

Advanced reasoning training

Behavioral: Advanced Reasoning Training

Interventions

Advanced Reasoning Training BEHAVIORAL

This is a strategy-based intervention to enhance frontal lobe function. Strategies equip participants to improve their strategic attention, integrated reasoning, and innovation abilities.

Also known as: Gist Reasoning Training

Cognitive training

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Must have physician or psychiatrist authorization form confirming participant fulfills 4 criteria:
• has diagnosis of Bipolar I or II
• has been stable and consistent with medication for last 3 months
• is in a euthymic, rather than manic or depressive, state
• is appropriate for a group-based intervention

You may not qualify if:

• Not a native English speaker
• Less than 12 years education
• Additional psychiatric diagnosis

Sponsors & Collaborators

• The University of Texas at Dallas: lead
• University of Texas: collaborator

Related Publications (5)

• Demant KM, Vinberg M, Kessing LV, Miskowiak KW. Effects of Short-Term Cognitive Remediation on Cognitive Dysfunction in Partially or Fully Remitted Individuals with Bipolar Disorder: Results of a Randomised Controlled Trial. PLoS One. 2015 Jun 12;10(6):e0127955. doi: 10.1371/journal.pone.0127955. eCollection 2015.

  PMID: 26070195 BACKGROUND

• Preiss M, Shatil E, Cermakova R, Cimermanova D, Ram I. Personalized cognitive training in unipolar and bipolar disorder: a study of cognitive functioning. Front Hum Neurosci. 2013 May 13;7:108. doi: 10.3389/fnhum.2013.00108. eCollection 2013.

  PMID: 23717272 BACKGROUND

• Deckersbach T, Nierenberg AA, Kessler R, Lund HG, Ametrano RM, Sachs G, Rauch SL, Dougherty D. RESEARCH: Cognitive rehabilitation for bipolar disorder: An open trial for employed patients with residual depressive symptoms. CNS Neurosci Ther. 2010 Oct;16(5):298-307. doi: 10.1111/j.1755-5949.2009.00110.x.

  PMID: 19895584 BACKGROUND

• Chapman SB, Mudar RA. Enhancement of cognitive and neural functions through complex reasoning training: evidence from normal and clinical populations. Front Syst Neurosci. 2014 Apr 28;8:69. doi: 10.3389/fnsys.2014.00069. eCollection 2014.

  PMID: 24808834 BACKGROUND

• Venza EE, Chapman SB, Aslan S, Zientz JE, Tyler DL, Spence JS. Enhancing Executive Function and Neural Health in Bipolar Disorder through Reasoning Training. Front Psychol. 2016 Nov 1;7:1676. doi: 10.3389/fpsyg.2016.01676. eCollection 2016.

  PMID: 27847486 DERIVED

MeSH Terms

Conditions

Bipolar Disorder

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mood Disorders; Mental Disorders

Results Point of Contact

• Title: Erin Venza, Research Clinician
• Organization: University of Texas at Dallas, Center for BrainHealth

erin.venza@utdallas.edu

972-883-3208

Study Officials

• Sandra Chapman, PhD

  The University of Texas at Dallas

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 14, 2016
• First Posted: July 25, 2016
• Study Start: April 1, 2014
• Primary Completion: September 1, 2015
• Study Completion: February 1, 2018
• Last Updated: December 6, 2024
• Results First Posted: December 6, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share