EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers

NCT02129387 | Completed DMC

• 1 other identifier: 1R01DA036032-01
• Study Type: observational
• Target: 115
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the proposal is to identify new predictors of smoking progression in young light smokers (YLS: 18-25 years \& cpd \< 5) using an 18-month longitudinal design and to relate these predictors of progression to the genetic profile most highly associated with smoking progression. A number of novel predictors will be assessed in 128 YLS. Predictors will include individual differences (IDs) in EEG, reward sensitivity, attentional performance, and mood during abstinence and in response to standardized and to self-selected acute nicotine doses (ANIC), as well as genetically influenced affective traits, and smoking history. The associations of a compelling genetic functional variant polymorphism, rs16969968, in the alpha5 nicotinic receptor subunit will also be related to smoking progression and the novel predictors. The study is expected to provide insights into IDs in mechanisms and predictors that contribute to smoking trajectories in YLS and thereby lead to targeted pharmacotherapy and behavioral interventions for at-risk YLS.

Conditions

Nicotine Dependence

Keywords

Nicotine; Smoking Progression; EEG; Young adults; Light smokers; rs1051730 genotype

Outcome Measures

Primary Outcomes (1)

• change in smoking and salivary cotinine concentration

  Change in smoking and salivary cotinine concentration from baseline to 18 months will be assessed at 3 month intervals-- 3, 6, 9, 12, 15, and 18 months after initial assessments.

  18 months

Secondary Outcomes (1)

• reason for change in smoke rate

  18 months after initial assessment

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Community sample of young light smokers

You may qualify if:

• smokers of 3 to 30 cigarettes per week for past 6 months

You may not qualify if:

• Smoking fewer than 3 or more than 30 tobacco cigarettes per week
• Never smoked more than 30 cigarettes per week
• Psychoactive drug use other than caffeine or occasional marijuana
• Current serious psychiatric diagnosis (e.g., major depressive disorder)
• Recent drug dependence
• Left-handed
• Color blind

Sponsors & Collaborators

• Southern Illinois University Carbondale: lead

Study Sites (1)

Southern Illinois University Carbondale Department of Psychology

Carbondale, Illinois, 62901-6502, United States

Location

Related Publications (2)

• Gunn MP, Rose GM, Whitton AE, Pizzagalli DA, Gilbert DG. Smoking Progression and Nicotine-Enhanced Reward Sensitivity Predicted by Resting-State Functional Connectivity in Salience and Executive Control Networks. Nicotine Tob Res. 2024 Sep 23;26(10):1305-1312. doi: 10.1093/ntr/ntae084.

  PMID: 38624067 DERIVED

• Whitton AE, Rabinovich NE, Lindt JD, Pergadia ML, Pizzagalli DA, Gilbert DG. Genetic and Depressive Traits Moderate the Reward-Enhancing Effects of Acute Nicotine in Young Light Smokers. Nicotine Tob Res. 2021 Aug 29;23(10):1779-1786. doi: 10.1093/ntr/ntab072.

  PMID: 33844007 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

blood, saliva

MeSH Terms

Conditions

Tobacco Use Disorder

Condition Hierarchy (Ancestors)

Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• David G Gilbert, PhD

  Southern Illinois University Carbondale

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 30, 2014
• First Posted: May 2, 2014
• Study Start: April 1, 2014
• Primary Completion: October 31, 2021
• Study Completion: November 30, 2021
• Last Updated: November 1, 2022

Record last verified: 2022-10

Locations

US (1)