Downhill Walking Training in COPD

NCT02113748 | Unknown

• 1 other identifier: ML10278
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized control trial will investigate whether a modality that generates more contractile muscle fatigue with lower ventilatory requirements render better results after a 12-week exercise training program in subjects with COPD. Subjects will be randomized to either exercise in a training program including downhill walking or to exercise in a training program including conventional walking.

Conditions

Pulmonary Disease, Chronic Obstructive

Keywords

Pulmonary disease, chronic obstructive; Downhill walking; exercise

Outcome Measures

Primary Outcomes (1)

• changes in 6-minute walking distance

  changes from baseline to Week 12

Study Arms (2)

Downhill walking training

EXPERIMENTAL

Exercise training including treadmill walking with a negative inclination.

Other: Downhill walking training

Conventional walking training

ACTIVE COMPARATOR

Exercise training including treadmill walking without inclination. Possible to progress training intensity with positive inclinations.

Other: Conventional walking training

Interventions

Downhill walking training OTHER

Walk on a treadmill with a negative inclination.

Downhill walking training

Conventional walking training OTHER

Walk on a treadmill without inclination. Possible to progress training intensity with positive inclinations

Conventional walking training

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with a primary diagnosis of COPD according to internationally accepted guidelines
• Patients referred to the outpatient PR program of Gasthuisberg University Hospital(Leuven, Belgium)

You may not qualify if:

• Any underlying disease or musculoskeletal limitation that could impair the ability to perform any of the exercise training modalities
• Absence of exacerbations in the previous month before entering the present study
• Patients included on the waiting list for lung transplantation

Sponsors & Collaborators

• KU Leuven: lead
• Research Foundation Flanders: collaborator
• Conselho Nacional de Desenvolvimento Científico e Tecnológico: collaborator

Study Sites (1)

University Hospitals Leuven

Leuven, Vl-Brabant, 3000, Belgium

RECRUITING

Related Publications (1)

• Camillo CA, Osadnik CR, Burtin C, Everaerts S, Hornikx M, Demeyer H, Loeckx M, Rodrigues FM, Maes K, Gayan-Ramirez G, Janssens W, Troosters T. Effects of downhill walking in pulmonary rehabilitation for patients with COPD: a randomised controlled trial. Eur Respir J. 2020 Sep 17;56(3):2000639. doi: 10.1183/13993003.00639-2020. Print 2020 Sep.

  PMID: 32444407 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Motor Activity

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Thierry Troosters, PhD

  KU Leuven

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Thierry Troosters, PhD

CONTACT

Thierry.Troosters@kuleuven.be

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: April 8, 2014
• First Posted: April 15, 2014
• Study Start: April 1, 2014
• Primary Completion: April 1, 2015
• Last Updated: April 15, 2014

Record last verified: 2014-04

Locations

BE (1)