NCT02108847

Brief Summary

The purpose of this study is to determine whether ultrasound guided fascia iliaca blocks performed before surgery help to reduce pain after elective total hip replacements.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
42

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Apr 2014

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 21, 2014

Completed
11 days until next milestone

Study Start

First participant enrolled

April 1, 2014

Completed
8 days until next milestone

First Posted

Study publicly available on registry

April 9, 2014

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2015

Completed
Last Updated

November 15, 2016

Status Verified

November 1, 2016

Enrollment Period

1 year

First QC Date

March 21, 2014

Last Update Submit

November 10, 2016

Conditions

Keywords

Arthroplasty, Replacement, HipPain, PostoperativeNerve BlockAnesthesia, RegionalFascia Iliaca BlockUltrasound Guided

Outcome Measures

Primary Outcomes (2)

  • Cumulative opioid consumption

    Dilaudid will be used for analgesia postoperatively. If there is a contraindication to Dilaudid, another opioid will be ordered for analgesia, and doses will subsequently be converted back to Dilaudid equivalent doses for comparison

    12 hours after surgery

  • Cumulative opioid consumption

    Dilaudid will be used for analgesia postoperatively. If there is a contraindication to Dilaudid, another opioid will be ordered for analgesia, and doses will subsequently be converted back to Dilaudid equivalent doses for comparison

    24 hours after surgery

Secondary Outcomes (4)

  • Cumulative opioid consumption

    4, 8, and 48 hours after surgery

  • Verbal pain score (static and dynamic)

    PACU, 4, 8, 12, 24, and 48 hours after surgery

  • Opioid side effect (nausea/vomiting, pruritus, constipation, urinary retention, sedation)

    PACU, 4, 8, 12, 24, and 48 hours after surgery

  • Overall patient satisfaction

    48 hours after surgery

Study Arms (2)

Fascia Iliaca Block - Ropivacaine

EXPERIMENTAL

Ultrasound guided fascia iliaca block performed preoperatively with 40 mL of 0.2% ropivacaine.

Drug: .2% RopivacaineProcedure: Fascia Iliaca Block

Fascia Iliaca Block - Saline

SHAM COMPARATOR

Ultrasound guided fascia iliaca block performed preoperatively with 40 mL of Saline.

Drug: SalineProcedure: Fascia Iliaca Block

Interventions

Fascia Iliaca Block - Ropivacaine
SalineDRUG
Fascia Iliaca Block - Saline

Ultrasound-guided regional anesthesia block to the groin area.

Fascia Iliaca Block - RopivacaineFascia Iliaca Block - Saline

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • American Society of Anesthesiologists' (ASA) score I, II or III
  • Scheduled for elective total hip arthroplasty

You may not qualify if:

  • Contraindication to regional anesthesia (allergy to local anesthetic, coagulopathy, infection or malignancy in the area)
  • Neurologic disorder affecting the ability to sense pain
  • Long term opioid use or chronic pain disorder
  • History of drug or alcohol abuse
  • Patient refusal
  • Pregnancy
  • Revision procedures
  • General anesthetic
  • Psychiatric or mental conditions that may affect assessment of outcomes

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Saskatoon City Hospital

Saskatoon, Saskatchewan, Canada

Location

Related Publications (8)

  • Chelly JE, Ben-David B, Williams BA, Kentor ML. Anesthesia and postoperative analgesia: outcomes following orthopedic surgery. Orthopedics. 2003 Aug;26(8 Suppl):s865-71. doi: 10.3928/0147-7447-20030802-08.

  • Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003 Aug;97(2):534-540. doi: 10.1213/01.ANE.0000068822.10113.9E.

  • Birnbaum K, Prescher A, Hessler S, Heller KD. The sensory innervation of the hip joint--an anatomical study. Surg Radiol Anat. 1997;19(6):371-5. doi: 10.1007/BF01628504.

  • Mitchell ME. Regional anesthesia for hip surgery. Techniques in Regional Anesthesia and Pain Management 3(2): 94-106, 1999.

    RESULT
  • Dalens B, Vanneuville G, Tanguy A. Comparison of the fascia iliaca compartment block with the 3-in-1 block in children. Anesth Analg. 1989 Dec;69(6):705-13.

  • Dolan J, Williams A, Murney E, Smith M, Kenny GN. Ultrasound guided fascia iliaca block: a comparison with the loss of resistance technique. Reg Anesth Pain Med. 2008 Nov-Dec;33(6):526-31. doi: 10.1016/j.rapm.2008.03.008.

  • Foss NB, Kristensen BB, Bundgaard M, Bak M, Heiring C, Virkelyst C, Hougaard S, Kehlet H. Fascia iliaca compartment blockade for acute pain control in hip fracture patients: a randomized, placebo-controlled trial. Anesthesiology. 2007 Apr;106(4):773-8. doi: 10.1097/01.anes.0000264764.56544.d2.

  • Godoy Monzon D, Iserson KV, Vazquez JA. Single fascia iliaca compartment block for post-hip fracture pain relief. J Emerg Med. 2007 Apr;32(3):257-62. doi: 10.1016/j.jemermed.2006.08.011. Epub 2007 Feb 8.

MeSH Terms

Conditions

Pain, Postoperative

Interventions

RopivacaineSodium Chloride

Condition Hierarchy (Ancestors)

Postoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and Symptoms

Intervention Hierarchy (Ancestors)

AnilidesAmidesOrganic ChemicalsAniline CompoundsAminesChloridesHydrochloric AcidChlorine CompoundsInorganic ChemicalsSodium Compounds

Study Officials

  • Jacelyn Larson, MD

    University of Saskatchewan

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
M.D.

Study Record Dates

First Submitted

March 21, 2014

First Posted

April 9, 2014

Study Start

April 1, 2014

Primary Completion

April 1, 2015

Study Completion

April 1, 2015

Last Updated

November 15, 2016

Record last verified: 2016-11

Locations