Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia
1 other identifier
interventional
29
1 country
1
Brief Summary
Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum. Noninvasive sensory stimulations such as peripheral electrical stimulation were reported to modulate the excitability of the motor excitability. Neuromuscular electrical stimulation (NMES) was proposed as a neuromodulation tool for the aberrant motor excitability on the SCA. This study aims to investigate the effect of NMES on the motor excitability in the SCA, and the differentiation on the central or peripheral motor excitability changed by the NMES.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2002
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2002
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2005
CompletedFirst Submitted
Initial submission to the registry
March 31, 2014
CompletedFirst Posted
Study publicly available on registry
April 3, 2014
CompletedApril 3, 2014
March 1, 2014
3.2 years
March 31, 2014
March 31, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Central Motor Excitability
Measure of changes in Central Motor Excitability by motor evoked potential and silent period that are measured by transcranial magnetic stimulation.
Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.
Peripheral Motor Excitability
Measure of changes in peripheral motor excitability by Maximum M wave and H reflex
Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.
Study Arms (3)
The SCA
EXPERIMENTALThe age-matched control
EXPERIMENTALThe young control
EXPERIMENTALInterventions
All groups received an accumulated 30-minute NMES (25 Hz, on/off: 800ms/800ms) intervention on median nerve.
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of Spinocerebellar ataxia
- No history of epilepsy
- No other neuromuscular disorder
- No fracture within the last six months and restricted movement on the upper extremity
- Limited trembling hand allowed for the EMG recording.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chang Gung University
Taoyuan District, 333, Taiwan
Related Publications (1)
Chen CC, Chuang YF, Yang HC, Hsu MJ, Huang YZ, Chang YJ. Neuromuscular electrical stimulation of the median nerve facilitates low motor cortex excitability in patients with spinocerebellar ataxia. J Electromyogr Kinesiol. 2015 Feb;25(1):143-50. doi: 10.1016/j.jelekin.2014.10.009. Epub 2014 Nov 1.
PMID: 25434572DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
March 31, 2014
First Posted
April 3, 2014
Study Start
August 1, 2002
Primary Completion
October 1, 2005
Study Completion
October 1, 2005
Last Updated
April 3, 2014
Record last verified: 2014-03