The Effect of Whole Body Vibration Training on Neuromuscular Property in Individuals With Ataxia

NCT01983631 | Completed DMC

• 1 other identifier: 100-1184B
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

The Cerebellum contains ten percent of the total volume of the brain and receives brain, spinal cord and vestibular sensory input. The organization of vestibular and somato-sensory afferent informations are also reported to be impaired in patients with cerebellum dysfunctions. Ataxia and impaired balance control are common symptoms in individuals with spinocerebellar ataxia (SCA). Previous studies have shown that patient with cerebellar damage are usually agonist and antagonist muscle coordination problem. Past studies also found the regulation of reciprocal Ia inhibition was impaired in patients with spinaocerebellar ataxia. In chronic phase, weakness might be developed due to deconditioned. All deficits mentioned above might lead to a decrease functional ability. Therefore, increasing somato-sensory and vestibular input, normalizing the modulation of recriprocal inhibition, and improve muscle strength might be able to improve the functional abilities of individuals with SCA. Recently, whole body vibration (WBV) has been trained for health groups. Studies showed that WBV training were able to improve muscle strength, balance control, and functional ability. However, there is no evidence showed that whether the whole body vibration training can affect the brain and spinal cord for the regulation of neural circuits. Whether also can affect for maximal voluntary contraction and improve central fatigue. No previous studies that whole body vibration training for SCA. Therefore, the purpose of this research was to investigate the intracortical facilitation and inhibition, reciprocal Ia inhibition, low frequency depression, maximal voluntary contraction, interpolated twitch technique to compare the different between the SCA and health subject. Also to investigate the short term and long term effect of WBV.

Conditions

Spinocerebellar Ataxia

Keywords

Whole body vibration; Reciprocal inhibition; Spinocerebellar ataxia; voluntary activation level

Outcome Measures

Primary Outcomes (4)

• Muscle twitch force

  Measure of changes in muscle twitch force by interpolation twitch technique

  Baseline, 4 weeks.

• Muscle voluntary activity level

  Measure of changes in muscle voluntary activity level by interpolation twitch technique.

  Baseline, 4 weeks

• Balance

  Measure of changes in berge balance scale and one-leg standing.

  Baseline, 4 weeks

• Severity of cerebellar ataxia

  Measure of changes in international cooperative ataxia rating scale(ICARS).

  Baseline, 4 weeks

Study Arms (4)

WBV group

EXPERIMENTAL

Stage 1: Short-term Whole body vibration(3 minutes in half-squatting position)

Other: Whole body vibration training

Non-WBV group

NO INTERVENTION

Stage 1 : Controlled group

training group

EXPERIMENTAL

Stage 2: Long-term WBV training (3 sessions per week for 4 weeks)

Other: Whole body vibration training

non-training group

NO INTERVENTION

Stage 2: Controlled group

Interventions

Whole body vibration training OTHER

WBV group; training group

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of spinocerebellar ataxia

Sponsors & Collaborators

• Chang Gung University: lead

Study Sites (1)

Chang Gung University

Taoyuan District, 333, Taiwan

Location

MeSH Terms

Conditions

Spinocerebellar Ataxias

Condition Hierarchy (Ancestors)

Cerebellar Ataxia; Cerebellar Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Spinocerebellar Degenerations; Spinal Cord Diseases; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Ataxia; Dyskinesias; Neurologic Manifestations; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: November 7, 2013
• First Posted: November 14, 2013
• Study Start: April 1, 2011
• Primary Completion: March 1, 2013
• Study Completion: March 1, 2013
• Last Updated: November 14, 2013

Record last verified: 2013-11

Locations

TW (1)