Role of Lung Ultrasound and Pulsed-wave Doppler in Lung Consolidations in Mechanically Ventilated Patients

NCT02100449 | Recruiting

• 1 other identifier: 14.005
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

In infectious lung consolidations, the inhibition of hypoxic pulmonary vasoconstriction (HPV) results in a higher regional acceleration time (RAcT) compared to the RAcT measured in atelectatic consolidations.

Conditions

Atelectasis; Pneumonia

Keywords

Atelectasis; Pneumonia; Lung ultrasound; Doppler

Outcome Measures

Primary Outcomes (1)

• RAcT in lung consolidations

  Regional acceleration time measured by lung ultrasound and pulsed-wave Doppler

  During lung ultrasound examination - Day 0

Secondary Outcomes (3)

• Presence of visible blood vessels on colour Doppler in lung consolidations

  During lung ultrasound examination - Day 0

• Presence of dynamic air bronchograms in lung consolidations

  During lung ultrasound examination - Day 0

• Presence of sub-pleural consolidations

  During lung ultrasound examination - Day 0

Study Arms (2)

Lung ultrasound and Doppler, pneumonia

OTHER

In this group, a lung ultrasound examination using pulsed-wave Doppler will be performed in patients with high clinical suspicion of pneumonia on Day 0. A bronchoalveolar lavage will also be performed on Day 0.

Other: Lung ultrasound and Doppler (Day 0)

Lung ultrasound and Doppler, atelectasis

OTHER

Patients without clinically active pulmonary disease but presenting a consolidation of suspected atelectatic nature. Fever, hypothermia, leucocytosis and leucopenia will not be present. Tracheal secretions will remain unchanged. There will be no deterioration of oxygenation. In this group, a lung ultrasound examination using pulsed-wave Doppler will be performed on Day 0.

Other: Lung ultrasound and Doppler (Day 0)

Interventions

Lung ultrasound and Doppler (Day 0) OTHER

In patients presenting a consolidation of suspected atelectatic nature, a lung ultrasound examination using pulsed-wave Doppler will be performed on Day 0.

Lung ultrasound and Doppler, atelectasis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Under mechanical ventilation and presenting one or more consolidations on chest radiography or CT scan

You may not qualify if:

• Participation to another study
• Poor echogenicity (morbid obesity, multiple thoracic dressings)
• Contra-indications to superior limbs or torso mobilization
• Contra-indications to bronchoscopy

Sponsors & Collaborators

• Centre hospitalier de l'Université de Montréal (CHUM): lead
• Centre de Recherche du Centre Hospitalier de l'Université de Montréal: collaborator

Study Sites (1)

Centre Hospitalier de l'Université de Montréal (CHUM)

Montreal, Quebec, H2X 3E4, Canada

RECRUITING

MeSH Terms

Conditions

Pulmonary Atelectasis; Pneumonia

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiratory Tract Infections; Infections

Study Officials

• Martin Girard, MD, FRCPC

  Centre hospitalier de l'Université de Montréal (CHUM)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Martin Girard, MD, FRCPC

CONTACT

514-890-8000; martin.girard@umontreal.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 27, 2014
• First Posted: April 1, 2014
• Study Start: June 1, 2014
• Primary Completion: November 1, 2024
• Study Completion: November 1, 2024
• Last Updated: February 8, 2024

Record last verified: 2024-02

Locations

CA (1)