NCT02098850

Brief Summary

The purpose of this evaluation is to record the management and outcome of adults with S.aureus bacteraemia (SAB) across multiple European, Asian and North American sites and to identify key quality indicators associated with improved outcome.

Trial Health

50
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
2,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2013

Typical duration for all trials

Geographic Reach
5 countries

24 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2013

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

March 25, 2014

Completed
3 days until next milestone

First Posted

Study publicly available on registry

March 28, 2014

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2015

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2016

Completed
Last Updated

December 3, 2014

Status Verified

December 1, 2014

Enrollment Period

2.3 years

First QC Date

March 25, 2014

Last Update Submit

December 2, 2014

Conditions

Staphylococcus Aureus Bacteremia

Keywords

Staphylococcus aureusbloodstream infectionbacteremia

Outcome Measures

Primary Outcomes (1)

  • Mortality

    90 Days

Secondary Outcomes (1)

  • Length of hospital stay

    90 Days

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patient in tertiary care hospitals

You may qualify if:

  • S. aureus (methicillin sensitive or resistant) isolated from one or more blood cultures

You may not qualify if:

  • Recurrent episodes of S. aureus bloodstream infection
  • Polymicrobial infection

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (24)

Uniklinik Koln

Cologne, North Rhine-Westphalia, 50935, Germany

RECRUITING

Uniklinik Freiburg

Freiburg im Breisgau, 79106, Germany

RECRUITING

Univeritatklinikum Schleswig-Holstein

Lübeck, 23562, Germany

RECRUITING

Seoul National University Bundang Hospital

Seoul, South Korea

RECRUITING

Hospital San Pau

Barcelona, 08026, Spain

RECRUITING

University Hospital Clinic de Barcelona

Barcelona, 08028, Spain

RECRUITING

Hospital Vall d'Hebron

Barcelona, 08035, Spain

RECRUITING

Hospital Universitario Son Espases

Palma. Mallorca, 79 07120, Spain

RECRUITING

Salamanca Hospital

Salamanca, Spain

RECRUITING

Hospital Universitario Virgen Macarena

Seville, 41007, Spain

RECRUITING

Hospital Universitario Virgen del Rocio

Seville, 41013, Spain

RECRUITING

Far Eastern Memorial Hospital

New Taipei City, Taiwan

RECRUITING

Birmingham Heartlands Hospital

Birmingham, West Midlands, B9 5SS, United Kingdom

RECRUITING

Brighton and Sussex University Hospitals

Brighton, BN2 5BE, United Kingdom

RECRUITING

Cambridge University Hospitals

Cambridge, CB2 0QQ, United Kingdom

RECRUITING

Hull and East Yorkshire Hospitals

Hull, HU3 2JZ, United Kingdom

RECRUITING

Royal Liverpool and Broadgreen Hospital

Liverpool, L7 8XP, United Kingdom

RECRUITING

Royal Free Hospital

London, NW3 2QG, United Kingdom

RECRUITING

Guy's and St Thomas'

London, SE1 7EH, United Kingdom

RECRUITING

Kings College Hospital

London, SE5 9RS, United Kingdom

RECRUITING

University College London Hospital

London, WC1E 6AG, United Kingdom

RECRUITING

Oxford University Hospitals

Oxford, OX3 9DU, United Kingdom

RECRUITING

Plymouth Hospitals

Plymouth, PL6 8DH, United Kingdom

RECRUITING

Portsmouth Hospitals

Portsmouth, PO3 6AD, United Kingdom

RECRUITING

Related Publications (1)

  • Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn MJ, Rieg S, Rodriguez-Bano J, Scarborough M, Seifert H, Soriano A, Tilley R, Torok ME, Weiss V, Wilson AP, Thwaites GE; ISAC, INSTINCT, SABG, UKCIRG, and Colleagues. Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies. J Infect. 2014 Mar;68(3):242-51. doi: 10.1016/j.jinf.2013.10.015. Epub 2013 Nov 16.

    PMID: 24247070BACKGROUND

MeSH Terms

Conditions

Staphylococcal InfectionsSepsisBacteremia

Condition Hierarchy (Ancestors)

Gram-Positive Bacterial InfectionsBacterial InfectionsBacterial Infections and MycosesInfectionsSystemic Inflammatory Response SyndromeInflammationPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Achim J Kaasch, MD

    University of Cologne

    STUDY CHAIR

Central Study Contacts

Achim J Kaasch, MD

CONTACT

+4922147832100

Christian M Bernasch

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
3 Months
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr. Achim Kaasch

Study Record Dates

First Submitted

March 25, 2014

First Posted

March 28, 2014

Study Start

January 1, 2013

Primary Completion

May 1, 2015

Study Completion

May 1, 2016

Last Updated

December 3, 2014

Record last verified: 2014-12

Locations

ES(7)TW(1)DE(3)KR(1)GB(12)