Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout

NCT02093611 | Completed

• 1 other identifier: MTI2013-CS04
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that is typically seen during repetitive sprints. This will give researchers a better understanding of the mechanism by which ATP supplementation can augment power, especially under high fatiguing conditions.

Conditions

Muscle Fatigue Caused by Repetitive Muscle Exercise

Outcome Measures

Primary Outcomes (1)

• Muscle Excitability

  Muscle excitability will be measured using Delsys Wireless Electromyography (EMG) sensors.

  Day 14

Secondary Outcomes (1)

• Power

  Day 14

Other Outcomes (2)

• Reaction Time

  Day 14

• Blood Biochemical Analyses

  Day 14

Study Arms (2)

Placebo

PLACEBO COMPARATOR

This arm will serve as the placebo supplementation.

Dietary Supplement: Placebo

ATP

ACTIVE COMPARATOR

This arm will serve as the treatment intervention, ATP

Dietary Supplement: ATP

Interventions

Placebo DIETARY_SUPPLEMENT

Also known as: Placebo Comparator

Placebo

ATP DIETARY_SUPPLEMENT

400 mg of ATP

Also known as: Peak ATP

ATP

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
• Must not have taken performance enhancing supplements for at least 3 months prior to the study start,
• Must be a non-smoker.
• Must not be taking amino acid supplements.
• Must not be using anabolic or catabolic hormones.
• Must not be taking any medications known to influence variables to be measured in the study.

You may not qualify if:

• Will not agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
• Has taken performance enhancing supplements for at least 3 months prior to the study start,
• Is currently a non-smoker.
• Is currently taking amino acid supplements.
• Is currently using anabolic or catabolic hormones.
• Is currently taking medications known to influence variables to be measured in the study.

Sponsors & Collaborators

• Metabolic Technologies Inc.: lead
• University of Tampa: collaborator

Study Sites (1)

Jacob M Wilson, PhD

Tampa, Florida, 33606, United States

Location

MeSH Terms

Interventions

Adenosine Triphosphate

Intervention Hierarchy (Ancestors)

Adenine Nucleotides; Purine Nucleotides; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Nucleotides; Nucleic Acids, Nucleotides, and Nucleosides; Ribonucleotides

Study Officials

• John A Rathmacher, PhD

  Metabolic Technologies Inc.

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 18, 2014
• First Posted: March 21, 2014
• Study Start: July 1, 2013
• Primary Completion: August 1, 2015
• Study Completion: August 1, 2015
• Last Updated: September 28, 2015

Record last verified: 2015-09

Locations

US (1)