The Effects of HMB, ATP, and HMB Plus ATP on Muscle Mass, Strength, and Power in Resistance Trained Athletes

NCT01508338 | Completed

• 1 other identifier: MTI2012-CS01
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to

• determine the effects of 12 weeks of HMB free acid gel, ATP, and HMB free acid gel plus ATP supplementation in trained individuals during a periodized training program on skeletal muscle hypertrophy, body composition, strength, force, velocity, and peak power during loaded and unloaded vertical jumps. Additionally, the study will determine if either supplementation protocol prevents the typical decay seen in performance following an overreaching cycle performed in the 9th and 10th weeks of the study. Finally, the study will elucidate the mechanisms of action of supplementation on protein breakdown by analyzing serum indices of muscle damage (CK, LDH) and anabolic status (Testosterone:Cortisol ratio) as well as a urinary indicator of protein breakdown (3-methylhistidine). We hypothesize that under these conditions that the supplementation protocols will augment skeletal muscle hypertrophy, strength, and power and that HMB will blunt increases in serum indices of muscle damage, and urinary indices of protein breakdown.

Conditions

Healthy Experienced Weight Training Males

Keywords

HMB beta-hydroxy-beta-methylbutyrate; ATP (adenosine-triphosphate); trained athletes

Outcome Measures

Primary Outcomes (1)

• Increased muscle strength, force, and power after intense weight training

  12 weeks

Secondary Outcomes (1)

• Increased muscle hypertrophy

  12 weeks

Study Arms (4)

Placebo

PLACEBO COMPARATOR

Dietary Supplement: Placebo

HMB

EXPERIMENTAL

Dietary Supplement: HMB

ATP and HMB

EXPERIMENTAL

Dietary Supplement: Peak ATP and HMB

ATP

EXPERIMENTAL

Dietary Supplement: ATP

Interventions

Placebo DIETARY_SUPPLEMENT

An oral placebo capsule will be taken each morning and three dosages of a placebo gel containing polydextrose will be taken 3 times daily for 12 weeks.

Placebo

HMB DIETARY_SUPPLEMENT

A placebo capsule will be taken each morning and three dosages of HMB gel, each providing 1 g of HMB, will be taken daily for a total of 3 g HMB per day for 12 weeks.

HMB

Peak ATP and HMB DIETARY_SUPPLEMENT

One capsule containing 400 mg of Peak ATP will be taken in the morning and three dosages of HMB gel, each providing 1 g of HMB, will be taken daily for a total of 3 g HMB per day for 12 weeks.

ATP and HMB

ATP DIETARY_SUPPLEMENT

One capsule containing 400 mg of Peak ATP will be taken daily in the morning and three dosages of a placebo gel containing polydextrose will be taken 3 times daily for 12 weeks.

ATP

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Have 3 years minimum of free weight training experience
• Can squat a minimum of 1.5 times their bodyweight
• Can bench press a minimum equal to their bodyweight
• Can deadlift a minimum of 1.5 times their bodyweight
• Are free of musculoskeletal injuries
• Have not taken creatine or HMB supplements for 6 weeks
• Are not taking amino acid supplements
• Are not using anabolic or catabolic hormones
• Are not taking medications that may interfere with study measurements
• Are not users of tobacco products

You may not qualify if:

• Do not have 3 years minimum of free weight training experience
• Can not squat a minimum of 1.5 times their bodyweight
• Can not bench press a minimum equal to their bodyweight
• Can not deadlift a minimum of 1.5 times their bodyweight
• Are not free of musculoskeletal injuries
• Have not taken creatine or HMB supplements in the past 6 weeks
• Are currently taking amino acid supplements
• Are using anabolic or catabolic hormones
• Are taking medications that may interfere with study measurements
• Use of tobacco products

Sponsors & Collaborators

• Metabolic Technologies Inc.: lead
• University of Tampa: collaborator

Study Sites (1)

University of Tampa

Tampa, Florida, 33606, United States

Location

Related Publications (1)

• Wilson JM, Joy JM, Lowery RP, Roberts MD, Lockwood CM, Manninen AH, Fuller JC, De Souza EO, Baier SM, Wilson SM, Rathmacher JA. Effects of oral adenosine-5'-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men. Nutr Metab (Lond). 2013 Sep 22;10(1):57. doi: 10.1186/1743-7075-10-57.

  PMID: 24330670 DERIVED

MeSH Terms

Interventions

Adenosine Triphosphate

Intervention Hierarchy (Ancestors)

Adenine Nucleotides; Purine Nucleotides; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Nucleotides; Nucleic Acids, Nucleotides, and Nucleosides; Ribonucleotides

Study Officials

• John A Rathmacher, PhD

  Metabolic Technologies Inc.

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 9, 2012
• First Posted: January 11, 2012
• Study Start: January 1, 2012
• Primary Completion: October 1, 2012
• Study Completion: October 1, 2012
• Last Updated: August 1, 2017

Record last verified: 2017-07

Locations

US (1)