Effects of 12 Weeks of Omega 3 Supplementation on Resting Metabolic Rate

NCT02092649 | Completed Results

• 1 other identifier: 14JA044
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

Fatty acids are the main components of the cell membranes. It has been demonstrated that diet can alter the characteristics and function of many membranes in the body, which has an effect on cardiovascular and metabolic health. Over the last two decades there has been a substantial rise in the research of the effects of Omega 3 polyunsaturated fatty acids on bodily function. There are two fatty acids that are of particular interest to researchers, eicosapentanoic acid (EPA) and docosahexanoic acid (DHA). These fatty acids have unique unsaturated structures, and their incorporation into biological membranes seems to generate important and positive physiological effects. The body is unable to synthesize these fatty acids in high concentrations to elicit significant effects, so they must be obtained through diet in food or via supplementation. It has been suggested that EPA and DHA supplementation increases resting metabolic rate (RMR) in humans, in part by increasing the use of fat as a fuel during rest. There are a limited number of studies examining the effects of Omega 3 supplementation on RMR. Some have found an increase in RMR while others have found no change. These studies have some limitations, as that they have either used a small sample size, a low omega fatty acid dose and/or short supplementation periods. Due to the variable results, the investigators will improve the reliability of the RMR measurements by making measures on each subject during two consecutive days at each time point that it is measured (0, 6 and 12 weeks). Therefore, the purpose of this study is to determine the effects of 12 weeks of omega 3 supplementation (3 g/d) on healthy young adults vs. the supplementation of a placebo. The researchers hypothesize that EPA and DHA supplementation will result in an increase in RMR and fat oxidation in some subjects and not in others. The duplicate RMR measures will determine the prevalence and magnitude of the omega 3 supplementation.

Conditions

Whole Body Energy Metabolism

Keywords

Omega-3; Resting metabolic rate; Eicosapentaenoic acid; Docosahexaenoic acid

Outcome Measures

Primary Outcomes (1)

• Change in Resting Metabolic Rate From Baseline

  Percent change in resting metabolic rate

  Baseline, 6 weeks, 12 weeks

Secondary Outcomes (5)

• Change in Maximum Oxygen Consumption From Baseline

  Baseline, 12 weeks

• Change in Whole Body Resting Fat Oxidation From Baseline

  Baseline, 6 weeks, 12 weeks

• Change in Whole Body Resting Carbohydrate Oxidation From Baseline

  Baseline, 6 weeks, 12 weeks

• Variability of Resting Metabolic Rate Measurement on 2 Consecutive Days

  Baseline, 6 weeks, 12 weeks

• Change in Fasted Blood Triglyceride Concentration From Baseline

  Baseline, 12 weeks

Study Arms (2)

Omega-3 Complete

EXPERIMENTAL

Oral ingestion of 3000 mg (5 capsules) of Omega-3 Complete (Jamieson Laboratories Ltd., Windsor, Ontario, Canada) per day for 12 weeks.

Dietary Supplement: Omega-3 Complete

Placebo Pill

PLACEBO COMPARATOR

Oral ingestion of 3 capsules of a placebo olive oil pill (Swanson Health Products, PO Box 2803 - Fargo, ND 58108 USA) per day for 12 weeks.

Dietary Supplement: Placebo Pill

Interventions

Omega-3 Complete DIETARY_SUPPLEMENT

Omega-3 Complete

Placebo Pill DIETARY_SUPPLEMENT

Placebo Pill

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years of age.
• Must currently practice a consistent diet and exercise regimen, and maintain this throughout the duration of the study.

You may not qualify if:

• Current or previous supplementation with omega-3's.
• Average fish intake greater than two times per week.
• Taken any medications, have any medical condition, and hospitalization or surgeries.
• Allergy to fish/fish oil, , (rosemary extract, ascorbyl palmitate, or natural tocopherols).

Sponsors & Collaborators

• University of Guelph: lead

Study Sites (1)

University of Guelph

Guelph, Ontario, N1G 2W1, Canada

Location

Related Publications (1)

• Jannas-Vela S, Roke K, Boville S, Mutch DM, Spriet LL. Lack of effects of fish oil supplementation for 12 weeks on resting metabolic rate and substrate oxidation in healthy young men: A randomized controlled trial. PLoS One. 2017 Feb 17;12(2):e0172576. doi: 10.1371/journal.pone.0172576. eCollection 2017.

  PMID: 28212390 DERIVED

Results Point of Contact

• Title: Sebastian Jannas-Vela MSc
• Organization: University of Guelph

sjannas@uoguelph.ca

(519)-824-4129

Study Officials

• Lawrence L Spriet, PhD

  University of Guelph

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Chair

Study Record Dates

• First Submitted: March 17, 2014
• First Posted: March 20, 2014
• Study Start: April 1, 2014
• Primary Completion: November 1, 2014
• Study Completion: January 1, 2015
• Last Updated: January 6, 2016
• Results First Posted: January 6, 2016

Record last verified: 2015-12

Locations

CA (1)