NCT02090335

Brief Summary

The goal of this project, which has not changed, is to improve the health and fitness of persons with serious mental illness (SMI) using an innovative model: In SHAPE Lifestyles. Participants are randomly assigned to the In SHAPE program or Health Club Membership and Education only. The three specific aims of this study are to:

  1. 1.To compare the treatment groups with respect to improvement in physical fitness outcomes, including: (a) health behaviors (engagement in exercise and diet changes); and (b) indicators of physical fitness.
  2. 2.To compare the treatment groups with respect to improvements in mental health outcomes, including negative symptoms, depression, and self-efficacy.
  3. 3.To explore differences in the treatment groups with respect to psychosocial functioning, health status, and acute service use, and the effects of selected demographic, clinical, and health behavior variables on primary outcomes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
210

participants targeted

Target at P75+ for not_applicable schizophrenia

Timeline
Completed

Started May 2007

Longer than P75 for not_applicable schizophrenia

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2007

Completed
6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2013

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

March 13, 2014

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 18, 2014

Completed
Last Updated

March 18, 2014

Status Verified

March 1, 2014

Enrollment Period

6 years

First QC Date

March 13, 2014

Last Update Submit

March 14, 2014

Conditions

Keywords

community mental healthhealth coachweight lossfitnessserious mental illnesshealth promotion

Outcome Measures

Primary Outcomes (1)

  • Change in Weight

    Change in weight over time was measured at baseline, 3-, 6-, 9-, 12-, and 18-months. Measures were weight (kg) and body mass index (kg/m2).

    Baseline, 3-, 6-, 9-, 12-, and 18-months

Secondary Outcomes (6)

  • Change in Dietary Behaviors

    Baseline, 6-, 12-, and 18-months

  • Change in Dietary Intake

    Baseline, 6-, 12-, and 18-months

  • Change in Serum lipids

    Baseline, 6-, 12-, and 18-months

  • Change in Blood Pressure

    Baseline, 6-, 12-, and 18-months

  • Change in Cardiorespiratory Fitness

    Baseline, 6-, 12-, and 18-months

  • +1 more secondary outcomes

Study Arms (2)

In SHAPE

EXPERIMENTAL

In SHAPE is a health promotion intervention consisting of a fitness club membership and a health promotion coach with basic certification as a fitness trainer, instruction on principles of healthy eating and nutrition, and training in tailoring individual wellness plans to the needs of persons with serious mental illness.

Behavioral: In SHAPEBehavioral: Fitness Club Membership

Fitness Club Membership

ACTIVE COMPARATOR

Fitness club membership with education in using the exercise equipment.

Behavioral: Fitness Club Membership

Interventions

In SHAPEBEHAVIORAL

In SHAPE is a health promotion intervention consisting of a fitness club membership and a health promotion coach with basic certification as a fitness trainer, instruction on principles of healthy eating and nutrition, and training in tailoring individual wellness plans to the needs of persons with serious mental illness.

In SHAPE

Fitness club membership with education in using the exercise equipment.

Fitness Club MembershipIn SHAPE

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • age 21 or older
  • serious mental illness defined by an axis I diagnosis of major depression, bipolar disorder, schizoaffective disorder, or schizophrenia
  • persistent impairment in multiple areas of functioning (e.g., work, school, self-care)
  • body mass index (BMI) greater than 25
  • able and willing to provide informed consent
  • on stable pharmacological treatment (same psychiatric medications over prior 2 months)

You may not qualify if:

  • residing in nursing home or other institution
  • diagnosis of dementia or significant cognitive impairment (MMSE\<24)
  • unable to walk one city block
  • pregnant or planning to become pregnant within the next 18 months
  • unable to speak English
  • terminal illness with life expectancy\<1 year
  • current diagnosis of an active substance dependence disorder

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Baycove Human Services

Boston, Massachusetts, 02114, United States

Location

Massachusetts Mental Health Center

Boston, Massachusetts, 02115, United States

Location

Vinfen

Cambridge, Massachusetts, 02141-1001, United States

Location

Related Publications (2)

  • Naslund JA, Aschbrenner KA, Pratt SI, Lohman MC, Scherer EA, McHugo GJ, Marsch LA, Unutzer J, Bartels SJ. Association Between Cardiovascular Risk and Depressive Symptoms Among People With Serious Mental Illness. J Nerv Ment Dis. 2017 Aug;205(8):634-640. doi: 10.1097/NMD.0000000000000669.

  • Bartels SJ, Pratt SI, Aschbrenner KA, Barre LK, Naslund JA, Wolfe R, Xie H, McHugo GJ, Jimenez DE, Jue K, Feldman J, Bird BL. Pragmatic replication trial of health promotion coaching for obesity in serious mental illness and maintenance of outcomes. Am J Psychiatry. 2015 Apr;172(4):344-52. doi: 10.1176/appi.ajp.2014.14030357. Epub 2014 Dec 12.

MeSH Terms

Conditions

SchizophreniaBipolar DisorderPsychotic DisordersWeight Loss

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental DisordersBipolar and Related DisordersMood DisordersBody Weight ChangesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Stephen J Bartels, MD, MS

    Dartmouth-Hitchcock Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Psychiatry, of Community and Family Medicine, and of TDI

Study Record Dates

First Submitted

March 13, 2014

First Posted

March 18, 2014

Study Start

May 1, 2007

Primary Completion

May 1, 2013

Study Completion

May 1, 2013

Last Updated

March 18, 2014

Record last verified: 2014-03

Locations