Effects of Sedentary Behaviour on Metabolic Parameters

NCT02088827 | Completed

• 1 other identifier: H13-01886
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The rates of sedentary activity are increasing. Studies have shown that time spent on doing sedentary activities is an independent risk factor for cardiovascular disease. Prior studies have shown that interrupting inactivity improved the body's handling of blood glucose and gene expression. The investigators plan to explore this further by examining the effects of interrupting 4 hours of inactivity with 2 minutes of moderate intensity exercise every 20 minutes on the following metabolic parameters: blood pressure, cortisol, C-Reactive Protein, glucose and insulin levels.

Conditions

Sedentary Lifestyle; Type 2 Diabetes

Keywords

Exercise; Sedentary Behaviour; Type 2 Diabetes; Older Adults

Outcome Measures

Primary Outcomes (1)

• Blood Pressure

  every 60 minutes for 4 hours

Secondary Outcomes (3)

• C Reactive Protein

  every 60 minutes for 4 hours

• Insulin Levels

  every 60 minutes for 4 hours

• Blood glucose levels

  every 60 minutes for 4 hours

Study Arms (2)

Activity

OTHER

During a 4 hour Meal Test subjects will cycle for 2 minutes every 20 minutes

Other: Activity

Inactivity

OTHER

During a 4 hour Meal Test study subjects will remain inactive (remain lying on a bed)

Other: Inactivity

Interventions

Inactivity OTHER

Subjects will remain inactive (lying on a bed) for 4 hours.

Inactivity

Activity OTHER

Subjects will spend 4 hours of inactivity (lying on a bed) broken up by 2 minutes of moderate intensity biking (on a stationary bike) every 20 minutes.

Activity

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• years of age or older
• type 2 diabetes managed with diet or oral hypoglycemic agents

You may not qualify if:

• using insulin to manage diabetes
• baseline of pre-session blood glucose reading equal to or greater than 10 mmol/L
• any medical condition that would limit the ability to perform activity portion of the study
• people not comfortable exercising on a stationary bicycle
• subject answers yes to one of more of the questions in the Physical Activity Readiness Questionnaire

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

Gerontology Research Lab

Vancouver, British Columbia, V5Z 1M9, Canada

Location

MeSH Terms

Conditions

Sedentary Behavior; Diabetes Mellitus, Type 2; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Kenneth M Madden, MSc, MD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head, VGH Division of Geriatric Medicine

Study Record Dates

• First Submitted: March 13, 2014
• First Posted: March 17, 2014
• Study Start: January 1, 2015
• Primary Completion: May 12, 2020
• Study Completion: September 1, 2021
• Last Updated: November 2, 2022

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)