Study Stopped
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Metabolic Phenotyping in Anorexia Nervosa
Metabolic Phenotyping to Predict Risk of Relapse in Patients With Anorexia Nervosa
2 other identifiers
observational
N/A
1 country
1
Brief Summary
After discharge from inpatient treatment, 30-50% of patients with Anorexia Nervosa require re-hospitalization within 4-12 months. So far, high relapse rates are mostly considered as lack of the patient's compliance and motivation to recover. However in studies, psychological relapse predictors explain only a minor part of the variance in relapse risk. Metabolic phenotyping has clinical value to predict weight course in obese patients and we assume that it could also be clinically relevant in patients with AN. We hypothesize that in patients with a dissipative but not with the thrifty phenotype, positive energy balance during refeeding causes an over proportional rise in energy expenditure, counteracts continuous weight gain during inpatient treatment, and increases relapse risk within one year after discharge. Thus we believe that metabolic phenotype as a biological parameter has prognostic value for the disease course in AN.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Oct 2014
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 3, 2014
CompletedFirst Posted
Study publicly available on registry
March 14, 2014
CompletedStudy Start
First participant enrolled
October 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2016
CompletedFebruary 13, 2017
February 1, 2017
1.8 years
January 3, 2014
February 10, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Relapse
1 year after discharge
Secondary Outcomes (2)
Metabolic phenotype
Baseline (during inpatient stay)
Biomarkers
Baseline (during inpatient stay)
Study Arms (2)
Anorexia Nervosa
Healthy controls
Eligibility Criteria
Female adolescents with Anorexia Nervosa
You may qualify if:
- Diagnosis of Anorexia Nervosa
- Between 12 and 18 years of age
- Written and informed consent of patient and parents
- Mental ability to understand the concept of the study
- Inpatient admission to Charité University Clinic with body weight below the 10th BMI-Percentile
You may not qualify if:
- Any further disease other than AN with significant influence on body composition and energy metabolism or its assessment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Charité University Clinic
Berlin, Germany
Related Publications (1)
Haas V, Stengel A, Mahler A, Gerlach G, Lehmann C, Boschmann M, de Zwaan M, Herpertz S. Metabolic Barriers to Weight Gain in Patients With Anorexia Nervosa: A Young Adult Case Report. Front Psychiatry. 2018 May 18;9:199. doi: 10.3389/fpsyt.2018.00199. eCollection 2018.
PMID: 29867616DERIVED
Biospecimen
Biomarkers of energy metabolism
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Verena K Haas, PhD
Charité University Berlin
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr. oec. troph. Verena Haas
Study Record Dates
First Submitted
January 3, 2014
First Posted
March 14, 2014
Study Start
October 1, 2014
Primary Completion
August 1, 2016
Study Completion
August 1, 2016
Last Updated
February 13, 2017
Record last verified: 2017-02