NCT04228939

Brief Summary

Inpatient treatment for patients with anorexia nervosa (AN) is recommended in extreme or severe cases after failure of outpatient treatment and is highly effective. However, a number of patients show symptom increase and relapse after discharge. The aim of this study is to evaluate the efficacy of a guided smartphone-based aftercare intervention following inpatient treatment of patients with AN to support symptom stabilization or continued improvement.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
184

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2019

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2019

Completed
1 year until next milestone

First Submitted

Initial submission to the registry

January 7, 2020

Completed
7 days until next milestone

First Posted

Study publicly available on registry

January 14, 2020

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2021

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2021

Completed
Last Updated

January 14, 2020

Status Verified

January 1, 2020

Enrollment Period

2.1 years

First QC Date

January 7, 2020

Last Update Submit

January 10, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Changes in Eating Disorder Severity (assessor-based)

    The Eating Disorder Examination (EDE) will be used to measure asessor-based eating disorder symptom severity over time.

    Measured at baseline (discharge), at week 16 (end of treatment) and 6 month follow-up

Secondary Outcomes (9)

  • Changes in Body-Mass-Index (BMI)

    Measured at baseline, week 16 and 6 month follow-up

  • Changes in Eating Disorder Severity (self-report)

    Measured at baseline, week 16 and 6 month follow-up

  • Changes in depressive symptoms

    Measured at baseline, week 16 and 6 month follow-up

  • Changes in stages of change regarding specific eating disorder behaviors

    Measured at baseline, week 16 and 6 month follow-up

  • Changes in self-efficay

    Measured at baseline, week 16 and 6 month follow-up

  • +4 more secondary outcomes

Study Arms (2)

Intervention group (IG)

EXPERIMENTAL
Behavioral: Recovery Record aftercare

Control group (CG)

ACTIVE COMPARATOR
Behavioral: Treatment as usual (TAU)

Interventions

Patients randomized to IG receive a therapist-guided smartphone-based aftercare intervention for a period of 16 weeks. The patients are invited to download for free the German version of "Recovery Record" at the App Store (iPhone) or the Google Play Store (android) to their smartphone and to link with the aftercare therapist. After discharge, patients are asked to monitor their meals at least three times per day (breakfast, lunch, and dinner), that is, to produce a minimum of three logs per day over the subsequent 16 weeks. Furthermore, patients are instructed to monitor their thoughts and feelings as well as their (disordered) behaviors. The aftercare therapist also sets the patients clinical post-discharge goals and makes coping skill suggestions. Individual therapist feedback is provided in-app twice per week during the first four weeks, once per week in weeks 4-8, every other week in weeks 8-12 and once in week 16.

Intervention group (IG)

Patients randomized to CG receive TAU i.e. patients and their physicians or therapists decide on post-discharge treatment which is documented at T1 and T2.

Control group (CG)

Eligibility Criteria

Age12 Years - 60 Years
Sexfemale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • primary diagnosis of AN (DSM-5: 307.1),
  • sex: female,
  • age: from 12 years onwards to 60 years,
  • regular completion of inpatient treatment,
  • at least a length of inpatient stay of 6 weeks,
  • BMI at discharge at least 15, at least a 1-point BMI increase during inpatient treatment,
  • owner of a smartphone,
  • informed consent of the patient and, in case of minors, also of the parents.

You may not qualify if:

  • major depression (BDI-II \> 29 at discharge),
  • suicidal tendency (item 9 of BDI-II \> 1 at discharge),
  • very high level of care after inpatient treatment (e.g. therapeutic living community, day clinic),
  • pregnancy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Schoen Clinic Roseneck

Prien am Chiemsee, 83209, Germany

RECRUITING

MeSH Terms

Conditions

Anorexia Nervosa

Interventions

Therapeutics

Condition Hierarchy (Ancestors)

Feeding and Eating DisordersMental Disorders

Study Officials

  • Sandra Schlegl, PhD

    Ludwig Maximilian University Munich

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 7, 2020

First Posted

January 14, 2020

Study Start

January 1, 2019

Primary Completion

January 31, 2021

Study Completion

July 31, 2021

Last Updated

January 14, 2020

Record last verified: 2020-01

Data Sharing

IPD Sharing
Will not share

Locations