The Factors That Affected the Outcome of Treatment of Congenital Nasolacrimal Duct Obstruction

NCT02081781 | Completed

• 1 other identifier: CGH-P103002
• Study Type: observational
• Target: 800
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study was to investigate various potential factors that affected the outcome of treatment of congenital nasolacrimal duct obstruction.

Conditions

Congenital Nasolacrimal Duct Obstruction

Outcome Measures

Primary Outcomes (1)

• probing success: both anatomical patency of the duct and functional free of symptoms

  one week

Study Arms (1)

Probing, topical anesthesia

Nasolacrimal duct obstruction (NLDO) is a quite common condition among the infants. An imperforate membrane at the distal end of the nasolacrimal duct is the main cause of occlusion. Children with the signs of NLDO presenting with epiphora and/or mucous discharge were included in this study. Intervention with probing under topical anesthesia was performed on the same surgeon. And success rate was evaluated.

Procedure: Probing

Interventions

Probing PROCEDURE

A punctal dilator was used for dilating the punctum. The nasolacrimal system was irrigated through either the lower or upper punctum with a hollow 23-gauge irrigating cannula attached to a syringe. A #0 (or #00) Bowman probe was passed through either the lower or upper canaliculus into the lacrimal sac and then directed downward through the nasolacrimal duct into nasal cavity. A "Hard" resistance could be felt as the probe touched the end of the nasolacrimal duct. A "Pop" tactile sensation might be noted while the probe passing through an obstruction at the valve of Hasner.

Probing, topical anesthesia

Eligibility Criteria

• Age: 1 Week - 5 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

primary care clinic

You may qualify if:

• a history of tearing and/or mucopurulent discharge beginning during the first few weeks of life
• anatomical nasolacrimal duct obstruction

You may not qualify if:

• previous probing
• glaucoma
• trauma
• lid malpositions
• craniofacial anomalies
• congenital mucocele of the nasolacrimal sac

Sponsors & Collaborators

• Cathay General Hospital: lead

Study Sites (1)

Department of Ophthalmology, Cathay General Hospital

Taipei, Taiwan, 106, Taiwan

Location

Related Publications (2)

• Pediatric Eye Disease Investigator Group; Repka MX, Chandler DL, Beck RW, Crouch ER 3rd, Donahue S, Holmes JM, Lee K, Melia M, Quinn GE, Sala NA, Schloff S, Silbert DI, Wallace DK. Primary treatment of nasolacrimal duct obstruction with probing in children younger than 4 years. Ophthalmology. 2008 Mar;115(3):577-584.e3. doi: 10.1016/j.ophtha.2007.07.030. Epub 2007 Nov 8.

  PMID: 17996306 BACKGROUND

• Miller AM, Chandler DL, Repka MX, Hoover DL, Lee KA, Melia M, Rychwalski PJ, Silbert DI; Pediatric Eye Disease Investigator Group; Beck RW, Crouch ER 3rd, Donahue S, Holmes JM, Quinn GE, Sala NA, Schloff S, Wallace DK, Foster NC, Frick KD, Golden RP, Lambert SR, Tien DR, Weakley DR Jr. Office probing for treatment of nasolacrimal duct obstruction in infants. J AAPOS. 2014 Feb;18(1):26-30. doi: 10.1016/j.jaapos.2013.10.016.

  PMID: 24568978 BACKGROUND

Study Officials

• Chih Heng Hung, M.D.

  Department of Ophthalmology, Cathay General Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 5, 2014
• First Posted: March 7, 2014
• Study Start: February 1, 2014
• Primary Completion: March 1, 2014
• Study Completion: March 1, 2014
• Last Updated: March 7, 2014

Record last verified: 2014-03

Locations

TW (1)